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Research Update

How Do We Help Depressed Smokers Quit?

October 1, 2024

Justin Morales, MD and Deepti Anbarasan, MD

Justin Morales, MD, and Deepti Anbarasan, MD. Drs. Morales and Anbarasan have no financial relationships with companies related to this material.

Tobacco smoking and major depression are highly comorbid, and depressed patients usually have a tougher time quitting than their non-depressed counterparts. In this research study, investigators compared the efficacy of anti-smoking medications in those with depression. The results may surprise you.

How to Use Varenicline (Chantix)

May 1, 2022

Stephen Wyatt, DO.

Steven A. Wyatt, DO. Adjunct faculty, University of North Carolina at Charlotte. Dr. Wyatt has disclosed no relevant financial or other interests in any commercial companies pertaining to this educational activity.

There are three medications with FDA approval for nicotine dependence: Nicotine replacement therapies, bupropion, and varenicline. Varenicline (Chantix) is arguably the most effective, but cost and concerns about neuropsychiatric side effects have limited its use, and a recent recall of the product temporarily stopped it entirely.

Efficacy and Acceptability of Varenicline for Alcohol Use Disorder

August 6, 2020

Richard Moldawsky, MD

Richard Moldawsky, MD Dr. Moldawsky has disclosed that he has no relevant financial or other interests in any commercial companies pertaining to this educational activity.

Smoking tobacco and drinking alcohol have reciprocal influences on each other. In this meta-analysis of nine randomized studies, the authors appraise the evidence for varenicline use for alcohol use disorder specifically.

Varenicline and Bupropion: Soaring Again With EAGLES?

November 22, 2019

Nicholas Rosenlicht, MD.

Nicholas Rosenlicht, MD. Dr. Rosenlicht has disclosed that he has no relevant financial or other interests in any commercial companies pertaining to this educational activity.

This research update unpacks the details behind the landmark “EAGLES” trial (Evaluating Adverse Events in a Global Smoking Cessation Study), which led to the removal of the varenicline black box warning.

Does Augmenting Varenicline with Bupropion Work Better than Varenicline Alone?

February 27, 2019

Jessica Goren, PharmD.

Jessica Goren, PharmD. Dr. Goren has disclosed that she has no relevant financial or other interests in any commercial companies pertaining to this educational activity.

We have a good array of smoking cessation treatments to choose from, including nicotine replacement therapy (NRT), bupropion, and varenicline. Varenicline is the most effective monotherapy agent, somewhat better than bupropion and single-product NRT, and comparable to combination NRT.