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Should You Test MTHFR?

May 5, 2025

Kellie Newsome, PMHNP and Chris Aiken, MD

MTHFR is a genetic test that aims to clarify who will respond to methylfolate in depression. But is it worth testing for?

Folate and Depression

April 28, 2025

Kellie Newsome, PMHNP and Chris Aiken, MD

We learn how psychiatrists figured out that low folate causes depression, and how the vitamin can treat depression even when serum levels are normal.

CLINICAL UPDATE

Complementary and Alternative Therapies for Late Life Depression

October 1, 2022

Neha Jain, MD

Neha Jain, MD. Assistant professor of psychiatry; medical director, mood and anxiety disorders program; assistant program director, geriatric psychiatry fellowship program, University of Connecticut Health Center.

Dr. Jain, author of this educational activity, has no relevant financial relationship(s) with ineligible companies to disclose.

A review of the research on depression in older patients favors physical activity, SAMe, and art and music therapy.

Low Vitamin B 12 Associated with Depression in Older Adults

July 1, 2022

Talya Shahal, MD.

Talya Shahal, MD. Dr. Shahal, author of this educational activity, has no relevant financial relationship(s) with ineligible companies to disclose.

Checking vitamin B12 levels in older adults is recommended, as low levels correlate with depression. This study did not show a similar association between folate levels and depression.

Is Watching ‘13 Reasons Why’ Bad for Teens?

August 12, 2019

Join Josh Feder, MD, and Mara Goverman, LICW, for a special episode focused on child psychiatry, suicidality, and the popular Netflix series 13 Reasons Why. The show stirred controversy when it portrayed the bullying and suicide of a teenager. Although the program increased awareness of these issues, some clinicians argued that...

The Choice: Deplin, Folate, or Folic acid

August 5, 2019

Folate, folic acid, l-methylfolate, Deplin, folinic acid… How do we choose among the many forms of this vitamin? All have proved useful as add-on therapies in depression, but they differ in important ways. Some may work in bipolar disorder, and there’s even one that might get in the way of...

l-Methylfolate for Depression: Costly Mistake or Good Thinking?

August 1, 2019

Folic acid and l-methylfolate are two versions of the same vitamin. Both are popular for antidepressant augmentation, but one is a expensive prescription. We compared them side-by-side and found that one has a slight advantage.