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Research Update

Efficacy of Deep Brain Stimulation for OCD

November 1, 2023

John Raiss, MD. Dr. Raiss has no financial relationships with companies related to this material.

Deep Brain Stimulation is a surgically invasive procedure that is used in an attempt to treat several conditions including obsessive compulsive disorder in some youths. But does it work? Read our research update so you can better guide families on this high-risk decision.

CLINICAL UPDATE

Trichotillomania: Diagnosis and Treatment

October 30, 2022

Michael Posternak, MD.

Michael Posternak, MD. Psychiatrist in private practice, Boston, MA. Dr. Posternak has no financial relationships with companies related to this material.

Trichotillomania (TTM) is a disorder that seems to lurk in the shadows. We hear about it but rarely see it.

Quetiapine in Bipolar With OCD

January 4, 2022

Richard Moldawsky, MD.

Richard Moldawsky, MD. Dr. Moldawsky has disclosed no relevant financial or other interests in any commercial companies pertaining to this educational activity.

OCD and bipolar disorder often occur together, and this randomized controlled trial looks at whether quetiapine can treat this comorbidity.

EXPERT Q&A

The Schizophrenia-OCD Overlap

September 28, 2021

Michael Poyurovsky, MD

Michael Poyurovsky, MD

Ma’ale HaCarmel Mental Health Center, Tirat Carmel, Israel; Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel. Dr. Poyurovsky has disclosed no relevant financial or other interests in any commercial companies pertaining to this educational activity.

OCD and schizophrenia often overlap, but treatment of this comorbidity is risky terrain. Dr. Poyurovsky explains when antidepressants should be avoided and details which antipsychotics are more likely to exacerbate OCD and which ones are more likely to help it.

SSRIs vs SNRIs in Pediatric Anxiety Disorders: Which Are More Tolerable?

July 14, 2021

John Raiss, MD.

John Raiss, MD. Dr. Raiss has disclosed no relevant financial or other interests in any commercial companies pertaining to this educational activity.

Which class of medication performs better for treating anxiety or OCD in children and adolescents, SSRI’s or SNRI’s? This study sorts through the comparative efficacy vs. side effects so that you can better decide how to help your patients.

CLINICAL UPDATE

How to Use Lamotrigine

January 1, 2021

Chris Aiken, MD.

Chris Aiken, MD. Editor-in-Chief of TCPR. Practicing psychiatrist, Winston-Salem, NC. Dr. Aiken has disclosed that he has no relevant financial or other interests in any commercial companies pertaining to this educational activity.

Lamotrigine is approved for the prevention of bipolar episodes, but Dr. Aiken explains why it may also treat active bipolar depression. This mood stabilizer is among the most tolerable in its class, and has additional benefits in OCD, borderline personality disorder, and depersonalization disorder.

New Augmentation Strategies in OCD

July 3, 2019

Michael Posternak, MD.

Michael Posternak, MD. Psychiatrist in private practice, Boston, MA. Dr. Posternak has disclosed that he has no relevant financial or other interests in any commercial companies pertaining to this educational activity.

Two medications show promise in OCD, and their mechanisms are novel: one glutamatergic, one dopaminergic.

Azithromycin for Acute-Onset Obsessive-Compulsive Disorder in Children

March 1, 2018

Thomas Jordan, MD

Thomas Jordan, MD Dr. Jordan has disclosed that he has no relevant financial or other interests in any commercial companies pertaining to this educational activity.

From obsessions, compulsions, and tics, to personality changes and oppositional behavior, the symptoms of PANS are wide-ranging. PANDAS is considered a subset of PANS that is temporally associated with a Group A streptococcal (GAS) infection.

Celecoxib as Adjunctive Treatment in Acute Mania

March 1, 2018

Thomas Jordan, MD

Thomas Jordan, MD Dr. Jordan has disclosed that he has no relevant financial or other interests in any commercial companies pertaining to this educational activity.

Emotional stress can trigger an inflammatory cascade response and increase blood levels of proinflammatory cytokines—including IL-1, IL-6, and tumor necrosis factor (TNF-α). These same inflammatory markers intensify in acute episodes of depression and mania.

Does Guanfacine Affect Tic Severity in Children With Chronic Tic Disorders?

November 1, 2017

Arian Ayon Verduzco, Pharm.D candidate (2018)

Arian Ayon Verduzco, Pharm.D candidate (2018) Ms. Verduzco has disclosed that she has no relevant financial or other interests in any commercial companies pertaining to this educational activity.

Tic disorders, including Tourette’s, often co-occur with ADHD, OCD, and anxiety disorders. Guanfacine is often tried for all of these conditions. Randomized placebo-controlled trials of immediate release guanfacine have been mixed, with one showing 31% improvement in tics but another showing no significant improvement.