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Home » schizophrenia

Articles Tagged with ''schizophrenia''

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KarXT (Cobenfy): The Breakthrough Antipsychotic That Could Change Everything

October 18, 2024
Jason Mallo, DO and Greg Malzberg, MD
In this video, we take an in-depth look at the recently FDA-approved antipsychotic, KarXT, also known by its brand name Cobenfy. This new drug represents a major breakthrough in schizophrenia treatment because, unlike traditional antipsychotics, it doesn’t rely on blocking dopamine receptors. Instead, KarXT works through a muscarinic agonist mechanism, making it a completely different approach to managing schizophrenia and other psychotic disorders.
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Research Update

How Long to Wait Before Changing Antipsychotics in Schizophrenia?

October 1, 2024
Lara Tang, MD
From The Carlat Hospital Psychiatry Report
Issue Links: Editorial Information | PDF of Issue

Lara Tang, MD. Dr. Tang has no financial relationships with companies related to this material.

How long should you wait before making changes after initiating an antipsychotic? The current study tested if early efficacy on an antipsychotic predicts subsequent efficacy, and its findings indicate benefits may be observed as quickly as two weeks. 


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Research Update

Antipsychotic Dosing: Differences Between Bipolar Mania and Schizophrenia

August 1, 2024
Kate J. Travis, MD
From The Carlat Psychiatry Report
Issue Links: Editorial Information | PDF of Issue

Kate Travis, MD. Dr. Travis has no financial relationships with companies related to this material.

Conventional wisdom suggests that antipsychotics need similar doses for mania and schizophrenia. This analysis clarifies the exceptions.


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Clinical Update

Causes of Psychosis in Older Adults

July 1, 2024
Julia Cromwell, MD and Christianne Gonzalez Davidson, MD
From The Carlat Geriatric Psychiatry Report
Issue Links: Editorial Information | PDF of Issue

Julia Cromwell, MD. Medical Director, Senior Adult Psychiatry Unit, Salem Hospital, Salem, MA.

Christianne Gonzalez Davidson, MD candidate 2024. Tufts University School of Medicine, Boston, MA.

Late-life psychosis has many causes—we’ll walk you through this important differential.


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Research Update

Aerobic Exercise Boosts Cognitive Training Benefits in Early ­Schizophrenia

July 1, 2024
Sébastien Hardy, PharmD, BCPS
From The Carlat Hospital Psychiatry Report
Issue Links: Editorial Information | PDF of Issue

Sébastien Hardy, MD. Dr. Hardy has no financial relationships with companies related to this material.

Incorporating a simple and low-cost intervention—aerobic exercise—into cognitive rehabilitation programs for patients with schizophrenia accelerates cognitive gains and improves school and work functioning.


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Research Update

Antipsychotic Polypharmacy: Maybe Not So Risky After All?

July 1, 2024
Sébastien Hardy, PharmD, BCPS
From The Carlat Hospital Psychiatry Report
Issue Links: Editorial Information | PDF of Issue

Sébastien Hardy, MD. Dr. Hardy has no financial relationships with companies related to this material.

The findings of this large study offer some reassurance about the safety and efficacy of antipsychotic polypharmacy, despite general treatment guidelines cautioning against it.



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Research Update

Does Menopause Increase Risk of Psychosis?

July 1, 2024
Briana Tillman, MD
From The Carlat Hospital Psychiatry Report
Issue Links: Editorial Information | PDF of Issue

Briana Tillman, MD. Dr. Tillman has no financial relationships with companies related to this material.

This comprehensive study highlights the need for gender-specific treatment in schizophrenia spectrum disorders, revealing that hormonal changes call for lower antipsychotic doses for female patients under 45 and higher doses for those who are post-menopausal.


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Expert Q&A

The Emerging Field of Lifestyle Psychiatry

July 1, 2024
Douglas Noordsy, MD
From The Carlat Hospital Psychiatry Report
Issue Links: Editorial Information | PDF of Issue

Douglas Noordsy, MD. 

Clinical Professor and Director of Lifestyle Psychiatry; Psychiatrist, INSPIRE Early Psychosis Clinic, Department of Psychiatry & Behavioral Sciences, Stanford University School of Medicine, Stanford, CA.

Dr. Noordsy has no financial relationships with companies related to this material.

Dr. Noordsy highlights compelling evidence suggesting that lifestyle changes, like regular exercise and nutritious diets, can significantly improve psychiatric treatment outcomes.


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Expert Q&A

Street Psychiatry: Providing Outreach and Care to the Unhoused Mentally Ill

July 1, 2024
Shayan Rab, MD
From The Carlat Hospital Psychiatry Report
Issue Links: Editorial Information | PDF of Issue

CHPR_ QA1_Shayan Rab_photo.jpegShayan Rab, MD

Associate Medical Director, Field-Based Services, Los Angeles County Department of Mental Health, Los Angeles, CA.

Dr. Rab has no financial relationships with companies related to this material.

Dr. Rab, pioneering street psychiatrist, shares the innovative methods he uses for effective outreach to unhoused mentally ill individuals, like mobile medication delivery and personalized housing strategies.


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Clinical Update

Don’t Delay: Interventions in Early Psychosis

July 1, 2024
Brian Holoyda, MD, MPH, MBA
From The Carlat Hospital Psychiatry Report
Issue Links: Editorial Information | PDF of Issue

Brian Holoyda, MD. Chief Psychiatrist, Contra Costa County Detention Health Services, Martinez, CA. Dr. Holoyda has no financial relationships with companies related to this material.

We highlight the profound difference early intervention makes in the trajectory of psychotic disorders, reducing symptom severity, suicide risk, and functional impairment.


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