Buprenorphine and methadone are both first-line treatments for opioid use disorder during pregnancy. Though this recommendation has been long-standing, it is based on a rather small study that is nearly 15 years old. In the current study, researchers revisit the question of how best to treat opioid use disorder during pregnancy with a large observational cohort study.

This study investigates whether augmenting risperidone with sertraline can improve negative symptoms. 

Methadone treatment for OUD typically comes with a high level of supervision whereas buprenorphine is often flexibly dosed and taken at home. Here researchers wanted to know how patients of a closely supervised methadone clinic compared with those taking buprenorphine prescribed in an office setting. The findings might surprise you.

A new analysis looks at the optimal dosing for quetiapine in schizophrenia, and when to use instant vs extended release.

SSRIs are often used in PTSD, but it is not clear that they work for all kinds of trauma. Trials of SSRIs are generally positive in women and people with a history of sexual trauma, while trials involving combat-related trauma tend to be negative. The current study aimed to better identify predictors of ­response.

Richard Moldawsky, MD. Dr. Moldawsky, author for this educational activity, has no relevant financial relationship(s) with ineligible companies to disclose.

Dosing recommendations for aripiprazole vary widely in depression, from 2 mg to 15 mg, but this meta-analysis finds a sweet spot in the lower range.