Is ketamine a glutamate antagonist or a spiritual kindler? Ketamine has two origin stories, each with its own understanding of how it treats depression. One came from the East, and one from the West, and after the Iron Curtain came down the two met face to face. Today, we tell that story.

Phase III clinical trials are beginning to roll out for psychedelic medications like like psilocybin and MDMA – also known as magic mushrooms and ecstasy. But this is not the first time these drugs have been used to treat mental illness, and today we take a dive into the clinical reports on psilocybin from half a century ago.

Experts in borderline personality disorder and bipolar disorder reach a consensus about the mercurial temperament that underlies borderline personality. The DSM Committee restores a diagnostic code to recognize those with a “clean bill of mental health,” and the word of the day goes psychedelic over the 5-HT2A receptor.

Nortriptyline + lithium is one of the top combos for keeping patients well after ECT, and in this episode we walk you through how to prescribe it, including side effects, dosing, drug levels, and drug interactions. Then, the word of the day: Antisocial personality disorder.

Barry Krakow, MD has spent his career studying and treating nightmares. In this interview, he shares how nightmares affect mental health, and how they point to more than just PTSD.

This deep dive podcast breaks through the dogma of autism intervention and helps you to understand the three main branches of autism intervention and their very different mechanisms, the quality of autism research with a huge shift in our understanding of what works, and addresses such questions as how many hours are really needed for intervention?

Our top 6 tips for managing nausea on psych meds, and a queasy tale of a tenacious problem to watch for when your patients who get nauseous: Conditioned taste aversion.

The APA says that genetic testing isn’t ready for prime time, but is there anything worth salvaging in these panels? We get some answers from John Nurnberger, MD, PhD, co-founder of the International Society of Psychiatric Genetics, the founding editor of the international journal Psychiatric Genetics, and a Distinguished Professor Emeritus at the Indiana University School of Medicine.

Guide your patients to light therapy with this tutorial, including how to select a device, what time to use it, and how to position the box.

Research updates on mirtazapine in anxiety, insomnia, methamphetamine abuse, and controversial news about the abuse potential of this antidepressant. Also new side effects and withdrawal symptoms discovered.