How long should we wait before changing an antipsychotic that doesn’t seem to be working? A large multicenter study finds that minimal symptom improvement by weeks two to four strongly predicts treatment failure and suggests an earlier switch can improve outcomes in schizophrenia.

This comprehensive study highlights the need for gender-specific treatment in schizophrenia spectrum disorders, revealing that hormonal changes call for lower antipsychotic doses for female patients under 45 and higher doses for those who are post-menopausal.

Antipsychotics offer remarkable, even lifesaving treatment for children and adolescents, however, their side effects include metabolic and neurologic problems, including neurotoxicity. This clinical update guides you through a rational process for employing these powerful medications when necessary but also reducing and discontinuing them when possible.

The management of bipolar disorder during pregnancy can be tricky. Some medications can be harmful to the fetus, and others need to be adjusted carefully due to changes in kidney and liver function. We walk you through the important considerations to keep in mind when working with these patients.

Delirium is widespread among patients in ICUs and surgery units. We review the workup and management of this common condition and give you tips to help prevent it in high-risk patients.