Does Extended-Release Naltrexone Worsen Psychiatric Symptoms?
The Carlat Addiction Treatment Report, Volume 7, Number 3&4, May 2019
Brian Frankel, MD.
Dr. Frankel has disclosed that he has no relevant financial or other interests in any commercial companies pertaining to this educational activity.
Extended-release (XR) naltrexone (Vivitrol) is an injectable version of naltrexone that lasts for 4 weeks and is FDA approved for opioid use disorder (OUD). Although effective, there is some concern that XR naltrexone may cause or worsen psychiatric symptoms because of its opioid blockade.