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  • Bipolar Disorder (July/August)
  • Current Issues in Bipolar Disorder Diagnosis: The Life Course Method

Current Issues in Bipolar Disorder Diagnosis: The Life Course Method

The Carlat Psychiatry Report, Volume 10, Number 7&8, July 2012
https://www.thecarlatreport.com/newsletter-issue/tcprv10n7-8/

From The Carlat Psychiatry Report, July 2012, Bipolar Disorder

Issue Links: Learning Objectives | Editorial Information | PDF of Issue

Topics: Bipolar Disorder

Print Friendly, PDF & Email

Descartes Li, MD

Clinical associate professor of psychiatry, University of California, San Francisco

Dr. Li has disclosed that he has no relevant relationship or financial interest in any commercial company pertaining to this educational activity.

How should we diagnose bipolar disorder? It isn’t always easy and current bipolar screening tools are problematic for a number of reasons. In my experience, the “Life Course Method” for clinical interviewing has proven to be effective. In this article, I’ll explain the reasons why and offer tips for using this tool.

Current Screening Tools
Current screening tools for bipolar disorder have been somewhat disappointing. The Mood Disorder Questionnaire (http://bit.ly/LdTheP) (Hirschfeld RM et al, J Clin Psychiatry 2003;64:45–59) yields lots of false positives but misses some true bipolar cases (for a review, see TCPR June 2010). Similarly, the Bipolar Spectrum Diagnostic Scale (http://bit.ly/K85MEN) (Ghaemi N et al, J Affect Disorders 2005;84:273–277) has not found widespread acceptance, possibly because patients sometimes have difficulty understanding it.

The Mini-International Neuropsychiatric Interview (MINI) (http://bit.ly/KWoXUN) (Sheehan DV et al, J Clin Psychiatry 1998;59 (suppl 20):22–33) uses the following screening question for mania/hypomania: “Have you ever had a period of time when you were feeling ‘up’ or ‘high’ or ‘hyper’ or so full of energy or full of yourself that you got into trouble, or that other people thought you were not your usual self?”

I rarely find questions like this to be useful. If the patient answers yes, I often end up asking about further symptoms of mania/hypomania, leading to variable or confusing answers—and I still don’t have a good sense of whether the patient had a manic episode or not. A “no” answer, likewise, does not rule out a manic episode.

So are any of the current screening tools useful? You could always use the Structured Clinical Interview for DSM-IV (SCID-IV), the “gold standard” in diagnosis for clinical research studies, but it can take two to three hours to administer, and most clinicians do not have the training or time for this. On the other hand, more familiar scales like the Altman Mania Rating Scale and the Young Mania Rating Scale are intended only to rate intra-episode severity and monitor treatment response. They are not intended as screening instruments. (For a review of rating scales for mania, see Picardi A, Curr Opin Psych 2009;22(1):42–49.)

My experience in teaching psychiatric residents how to diagnose bipolar disorder led me to carefully observe the strategies of experienced clinicians. Expert clinicians seem to employ a strategy, or set of strategies, that I call the Life Course Method (not to be confused with the NIMH Life Chart Method, a tool to follow treatment outcomes in patients with bipolar disorder).

Clinical Pearls

  • Use collateral information whenever possible
  • Screen for mania in the time periods right before depressions
  • Focus on behavioral activation or life events rather than on patient report of mood elevation
  • Screen depressive episode for manic/hypomanic symptoms to diagnose mixed episodes

The Life Course Method: Get a Story
This method basically involves getting a good, solid clinical history from the beginning. I usually start with the question: When did you first start experiencing mood symptoms? Then I proceed chronologically, with special attention to mood episodes and significant life events. I like to divide the history into academic/occupational time periods, or epochs: How was high school? How was college? Your first job? Patients in their mid-twenties often have excellent recall for events during school years. Moreover, asking about whether an event occurred in freshman versus sophomore year of college is often easier than asking about 1994 or 1995. For older patients, life events such as marriage/divorce, job changes, periods of disability, or geographic relocations can help anchor the history. In addition, these life events may be concurrent with manic or hypomanic episodes. Behavioral changes, such as increased risky pleasurable behaviors or pressured speech, are often better markers for manic/hypomanic episodes than patient recall of mood elevations (Akiskal HS and Benazzi F, J Clin Psychiatry 2005;66:914–921), so ask for behavior changes first, then follow up with mood inquiries to nail down the diagnosis.

A sample series of questions might look like this: Why did you move to Maine? So you decided to start lobstering, I see. What was your daily life like at that time? How about your mood? Did your [mood symptom] get so bad that you couldn’t work? Why did you
move back?

I try to link events together into a life story to develop a baseline and trajectory for a person’s life. A process of this kind can be quite memorable and I often literally get “where patient is coming from.” Collateral information is helpful when I am at a loss to understand the patient, or am left with a bunch of symptoms that don’t fit together. A family member who knows the patient well can confirm, clarify, or refute important details. Also, a review of mania/hypomania symptoms during depressive episodes sometimes yields a discovery of a mixed episode. Finally, I make sure to explore the period right before a depressive episode because sometimes the patient has forgotten about a mania that preceded it.

Advantages
A particular advantage of the Life Course Method is that most of what’s important in treating bipolar disorder—triggers, age of onset, response to medications, number of episodes—are reviewed in the normal course of the interview, without having to memorize a list of questions. Remember to ask about functional impact of mood symptoms, keeping in mind that other diagnoses or co-morbidities (eg, substance abuse or anxiety disorders) may cause more impairment than mood complaints.

The Life Course Method makes the history much more memorable. Once the interview has been completed, a quick review of the patient’s record can bring back the person’s life story with surprising speed and vividness. If the interview is chronological, gaps in the history become quickly apparent and can be noted for future exploration. This method also often engages the patient in the interview process and begins the psycho-educational process, especially as patterns emerge and previously inexplicable mood symptoms are seen to have predictability.

Disadvantages
The Life Course Method can take a lot of time, so being efficient is critical. I advise inexperienced clinicians to obtain only enough information so as to confirm a diagnosis and obtain other relevant information, rather than spending a lot of time on florid manic episodes. I also recommend focus on the earliest symptoms of an episode, because these represent signals for future early intervention. However, the most important factor in improving efficiency is practice, and if possible, observation of expert clinicians.

The Life Course Method

  1. Start from the beginning of patient’s history of mood/psychiatric problems
  2. Divide history into epochs of time
  3. Go chronologically forward with special attention to mood episodes and significant life events
  4. For each mood episode, obtain prodromal symptoms, medications tried and their efficacy, adherence to medications
  5. Get a story!
TCPR Verdict: 
No convenient, foolproof methods have emerged in routine screening for bipolar disorder. The Life Course Method is basically just good clinical interviewing with a longitudinal perspective. But it makes clinical interviewing memorable, engaging and (dare I say) fun.

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Prescribing Psychotropics: From Drug Interactions to Genetics
The Child Medication Fact Book for Psychiatric Practice (2018)
Issues Archives

2022

  • Race and Mental Health (May)
  • Thyroid and Mental Illness (April)
  • Living With Mental Illness (March)
  • Schizophrenia (February)
  • The Difficult Patient (January)

2021

  • Bipolar Disorder (November/December)
  • Mood Disorders (October)
  • Overdiagnosis (September)
  • Therapy (August)
  • Depression (June/July)
  • Problems with Generics (May)
  • Metabolism and Mental Health (April)
  • Stopping Psych Meds Part 2 (March)
  • Stopping Psych Meds Part 1 (February)
  • Mind-Gut Connection (January)

2020

  • Esketamine (January)
  • Telepsychiatry (May)
  • Mind-Gut Connection (January)
  • Practical Psychotherapy (November/December)
  • Mood and Menopause (October)
  • When to Use Lithium (September)
  • Traumatic Brain Injury (August)
  • Borderline Personality Disorder (June/July)
  • Psychopharmacology Algorithms (April)
  • Bipolar II (March)
  • Inflammation and Depression (February)

2020

  • Mood Disorders in Children and Adolescents (Oct/Nov/Dec)
  • Identity & Culture in Children and Adolescents (July/August/September)
  • Psychosis in Children and Adolescents (April/May/June)
  • ADHD in Children and Adolescents (Jan/Feb/Mar)

2020

  • Harm Reduction (January/February)
  • Substance Use in Health Professionals (March/April)
  • Alternative Treatment in Addiction (November/December)
  • Social Aspects of Addiction (September/October)
  • Opioid Use Disorder Treatment (July/August)
  • Emerging Risks for Old Medications (May/June)

2019

  • Depression (May)
  • Adult ADHD (November/December)
  • Mental Health Apps (October)
  • How to Talk about Medication (September)
  • Side Effects Part II (August)
  • Side Effects Part I (June/July)
  • Sleep (April)
  • Parenting, Pregnancy, and Prevention (March)
  • Dark and Light Therapy (February)
  • Deprescribing (January)

2018

  • Drug Metabolism (November/December)
  • Working With Transgender Patients (October)
  • Emergency Psychiatry (September)
  • Treatment-Resistant Depression (July/August)
  • Neurobiology (June)
  • Anxiety (May)
  • Neurofeedback (April)
  • Antipsychotics Update (March)
  • Working With Families (February)
  • Bipolar Disorder (January)

2017

  • PTSD (December)
  • Retirement (November)
  • Intellectual Disability (September/October)
  • Antidepressants (July/August)
  • Personality Disorders (June)
  • Dementia (May)
  • Cognitive Behavior Therapy Techniques (April)
  • Pharmacogenetics (March)
  • Treating Psychosis (February)
  • Adult ADHD (January)

2016

  • Complementary and Alternative Medicine in Psychiatry (November/December)
  • Side Effects (October)
  • Pain Management (September)
  • Medication in Pregnancy (July/August)
  • Psychoanalysis in Modern Psychiatry (June)
  • Correctional Psychiatry (May)
  • Antidepressant Roundup (April)
  • Burnout (March)
  • Private Practice (February)
  • Bipolar Disorder (January)

2015

  • Psychiatry and General Medicine (November/December)
  • Biomarkers in Psychiatry (May)
  • Telepsychiatry (October)
  • Sleep Disorders (September)
  • Interventional Psychiatry (July/August)
  • Eating Disorders (June)
  • Psychotherapy Updates (April)
  • Topics in Geriatric Psychiatry (March)
  • Antipsychotics Update (February)
  • Risk Management (January)

2014

  • Bipolar Disorder (November/December)
  • Pharmacogenetics (October)
  • Keeping up in Psychiatry (September)
  • Research in Psychiatry (July/August)
  • Marijuana (June)
  • Psychiatric Diagnosis (May)
  • Issues in Psychopharmacology (April)
  • Schizophrenia (March)
  • Women’s Psychiatry (February)
  • Ethics in Psychiatry (January)

2013

  • Military Psychiatry (December)
  • Depression (November)
  • Treatment of Dementia (October)
  • Anxiety Disorders (September)
  • Natural and Alternative Treatments in Psychiatry (July/August)
  • Autism Spectrum Disorder (June)
  • Practice Tips (May)
  • Substance Abuse (April)
  • Medicolegal Topics (March)
  • End of Life Care (February)
  • Antipsychotic Update (January)

2012

  • Screening Tools and Tips (December)
  • Medical Comorbidities (November)
  • Devices in Psychiatry (October)
  • Eating Disorders (September)
  • Bipolar Disorder (July/August)
  • Risk Management (June)
  • Antidepressant Roundup 2012 (May)
  • Gender and Sexuality (April)
  • Personality Disorders (March)
  • ADHD (February)
  • Natural Treatments in Psychiatry (January)

2011

  • Electronic Medical Records (December)
  • Insomnia (November)
  • Psychotherapy (October)
  • Alcoholism (September)
  • Anxiety Disorders (July/August)
  • Schizophrenia (June)
  • Managing Side Effects (May)
  • Antidepressant Roundup 2011 (April)
  • DSM-5 and Diagnostic Issues (March)
  • Drug-Drug Interactions (February)
  • Bipolar Disorder (January)

2010

  • Hospital Psychiatry (December)
  • Psychiatric Medication in Pregnancy (November)
  • Maintenance of Certification (October)
  • The Neuroscience of Psychotherapy (September)
  • Treatment of Depression (July/August)
  • Email and the Internet in Psychiatry (June)
  • Substance Abuse (May)
  • The Diagnosis and Treatment of Dementia (April)
  • Ethics in Psychiatry (March)
  • Natural Treatments in Psychiatry (February)
  • ADHD (January)

2009

  • Treating Schizophrenia (December)
  • Treatment for Anxiety Disorders (November)
  • The Latest on Antidepressants (October)
  • Topics in Neuropsychiatry (September)
  • The Interface of Medicine and Psychiatry (July/August)
  • Generic Medications in Psychiatry (June)
  • The Treatment of Eating Disorders (May)
  • Healthcare Policy and Psychiatry (April)
  • Antipsychotic Roundup 2009 (March)
  • Psychiatric Medication in Pregnancy and Lactation (February)
  • Transcranial Magnetic Stimulation (January)

2008

  • Treating Fibromyalgia and Pain in Psychiatry (December)
  • Issues in Child Psychiatry (November)
  • Improving Psychiatric Practice (October)
  • Treating Personality Disorders (September)
  • Bipolar Disorder (July/August)
  • Antipsychotic Roundup 2008 (June)
  • Atypical Antipsychotics in Clinical Practice (February)
  • Neuropsychological Testing (May)
  • Psychiatric Medications: Effects and Side Effects (April)
  • Update on Substance Abuse (March)
  • Anticonvulsants in Psychiatry (February)
  • Brain Devices in Psychiatry (January)

2007

  • The Treatment of Insomnia (December)
  • Avoiding Malpractice in Psychiatry (November)
  • Update on Eating Disorders (October)
  • Complex Psychopharmacology (September)
  • Laboratory Testing in Psychiatry (August)
  • Psychotherapy in Psychiatry (July)
  • Posttraumatic Stress Disorder (June)
  • Topics in Geriatric Psychiatry 2007 (May)
  • Pregnancy and Menopause in Psychiatry (Apil)
  • Antipsychotic Roundup 2007 (March)
  • Understanding Psychiatric Research (February)
  • Antidepressant Round-up 2007 (January)

2006

  • Technology and Psychiatric Practice (December)
  • The Use of MAOIs (November)
  • Medication Treatment of Depression (January)
  • Seasonal Affective Disorder (October)
  • Treatment of ADHD (September)
  • Topics in Bipolar Disorder (August)
  • Neurotransmitters in Psychiatry (July)
  • Treating Substance Abuse (June)
  • The STAR*D Antidepressant Trial (May)
  • Natural Treatments in Psychiatry (April)
  • Medication Treatment of Anxiety (March)
  • Panic Disorder: Making Treatment Work (March)
  • Antipsychotic Roundup 2006 (February)
  • Antidepressant Roundup 2006 (January)

2005

  • Self-Help Books and Psychiatry (December)
  • Genetics and Psychiatry (November)
  • Pregnancy and Psychiatric Treatment (October)
  • Benzodiazepines and Hypnotics in Psychiatry (September)
  • Geriatric Psychiatry Update (August)
  • Chart Documentation in Psychiatry (July)
  • The Treatment of Bipolar Disorder (June)
  • Weight Loss and Smoking Cessation in Psychiatry (May)
  • Treating ADHD (April)
  • Drug Industry Influence in Psychiatry (March)
  • Atypical Antipsychotics 2005 (February)
  • Antidepressant Roundup 2005 (January)

2004

  • Sexual Dysfunction (December)
  • Suicide Prevention (November)
  • To Sleep, To Awake (October)
  • Women’s Issues in Psychiatry (September)
  • OCD: An Update (August)
  • Chronic Pain and Psychiatry (July)
  • Neuroimaging in Psychiatry (June)
  • Natural Medications in Psychiatry (May)
  • Posttraumatic Stress Disorder (April)
  • Treatment of Alcoholism (March)
  • Battle of the Atypicals (February)
  • Antidepressant Roundup, 2004 (January)

2003

  • Research Methods in Psychiatry (December)
  • Antidepressants in Children (November)
  • The Treatment of Dementia (October)
  • Bipolar Disorder, Part II: The Novel Anticonvulsants (September)
  • Bipolar Disorder: The Basics (August)
  • Drug-Drug Interactions in Psychiatry (July)
  • Managing Antidepressant Side Effects (June)
  • Antidepressants in Pregnancy and Lactation (May)
  • ADHD: Medication Options (April)
  • Panic Disorder: Making Treatment Work (March)
  • Atypical Antipsychotics in Clinical Practice (February)
  • Medication Treatment of Depression (January)

2019

  • Autism in Children and Adolescents (November/December)
  • Depression in Children and Adolescents (May/June/July/August)
  • Substance Use in Children and Adolescents (September/October)
  • Trauma in Children and Adolescents (March/April)
  • Anxiety in Children and Adolescents (January/February)

2018

  • Psychotropic Risks in Children and Adolescents (May/June)
  • ADHD in Children and Adolescents (November/December)
  • Depression in Children and Adolescents (September/October)
  • Autism in Children and Adolescents (July/August)
  • Anxiety in Children and Adolescents (March/April)
  • Suicide in Children and Adolescents (January/February)

2017

  • Adolescents (November/December)
  • ADHD in Children and Adolescents (September/October)
  • Psychosis in Children and Adolescents (August)
  • PANDAS, PANS, and Related Disorders (June/July)
  • Marijuana in Children and Adolescents (May)
  • Tourette’s and Other Tic Disorders in Children and Adolescents (March/April)
  • Autism in Children and Adolescents (January/February)

2016

  • Gender Dysphoria in Children and Adolescents (November/December)
  • Technology Issues With Children and Adolescents (September/October)
  • Mood Dysregulation in Children and Adolescents (July/August)
  • Eating Disorders in Children and Adolescents (May/June)
  • Conduct Disorder in Children and Adolescents (April)
  • Sleep Disorders in Children and Adolescents (March)
  • ADHD in Children and Adolescents (January/February)

2015

  • Antidepressant Use in Children (November/December)
  • Foster Care and Child Psychiatry (September/October)
  • Autism (July/August)
  • Trauma (May/June)
  • Anxiety Disorders (April)
  • Schools and Psychiatry (March)
  • Emergency Psychiatry in Children (January/February)

2014

  • Antipsychotics in Children (December)
  • ADHD (November)
  • Gender and Sexuality (September/October)
  • Psychotic Symptoms (Summer)
  • Medication Side Effects (May)
  • Food and Mood (April)
  • Learning and Developmental Disabilities (February)

2013

  • Complex Practice Issues (December)
  • Diet and Nutrition (November)
  • Child Psychiatry in DSM-5 (August/September)
  • Medication Side Effects and Interactions (June/July)
  • Problematic Technology (March/April)
  • Autism Spectrum Disorders (January/February)

2012

  • Bipolar Disorder (December)
  • Substance Abuse (October/November)
  • Transitional Age Youth (July/August)
  • Rating Scales (May/June)
  • Eating Disorders (March/April)
  • Behavioral Disorders (February)

2011

  • Treatment of Anxiety Disorders (December)
  • Trauma (November)
  • Bullying and School Issues (October)
  • Hidden Medical Disorders (August)
  • OCD and Tic Disorders (June)
  • Suicide and Non-Suicidal Self Injury (April)
  • Sleep Disorders (March)
  • ADHD (January)

2010

  • Use of Antipsychotics in Children and Adolescents (December)
  • Learning and Developmental Disabilities (October)
  • Major Depression (September)
  • Treating Children and Families (July)
  • The Explosive Child (May)

2019

  • Dual Diagnosis in Addiction Medicine (May/June)
  • Medical Issues in Addiction Practice (November/December)
  • Alcohol Addiction (September/October)
  • Legal Issues in Addiction Medicine (July/August)
  • Traumatic Brain Injury and Addiction (March/April)
  • Board Certification in Addiction Medicine (January/February)

2018

  • Opioid Addiction (November/December)
  • Addiction in Older Adults (October)
  • Sleep Disorders and Addiction (September)
  • Adolescent Addiction (July/August)
  • Pain and Addiction (May/June)
  • Cannabis and Addiction (March/April)
  • Stigma and Addiction (January/February)

2017

  • Pregnancy and Addiction (November/December)
  • Detox (Sepember/October)
  • Dual Diagnosis (August)
  • Alternatives to 12-Step Programs (June/July)
  • Recovery (May)
  • Psychiatric Uses of Street Drugs (March/April)
  • Sex Addiction (January/February)

2016

  • Prescription Drug Monitoring Programs (PDMPs) (November/December)
  • Addiction in Health Care Professionals (September/October)
  • Dialectical Behavior Therapy in Addiction (August)
  • Motivational Interviewing (June/July)
  • Benzodiazepines (May)
  • Opioid Addiction (March/April)
  • Families and Substance Abuse (January/February)

2015

  • The Twelve Steps (November/December)
  • Designer Drugs (September/October)
  • Residential Treatment Programs Decoded (July/August)
  • Nicotine and E-Cigarettes (June)
  • Drug Screening (April/May)
  • Integrating Therapy and Medications for Alcoholism (March)
  • Detoxification Protocols (January/February)

2014

  • Behavioral Addictions (December)
  • Risk and Reimbursement (November)
  • Stimulant Abuse (September/October)
  • Self-Help Programs (June)
  • Opioid Addiction (May)
  • Coping with Bad Outcomes (March)
  • Change Management in Addiction Treatment (January/February)

2013

  • Cocaine Addiction (December)
  • Relapse Prevention (November)
  • Cannabis Addiction (August/September)
  • Addiction in DSM-5 (June/July)
Editor-in-Chief

Chris Aiken, MD

Dr. Aiken is the director of the Mood Treatment Center in North Carolina, where he maintains a private practice combining medication and therapy along with evidence-based complementary and alternative treatments. He has worked as a research assistant at the NIMH and a sub-investigator on clinical trials, and conducts research on a shoestring budget out of his private practice.

Full Editorial Information

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