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  • Substance Abuse (May)
  • Suboxone: An Overview

Suboxone: An Overview

The Carlat Psychiatry Report, Volume 8, Number 5, May 2010
https://www.thecarlatreport.com/newsletter-issue/tcprv8n5/

From The Carlat Psychiatry Report, May 2010, Substance Abuse

Issue Links: Learning Objectives | Editorial Information | PDF of Issue

Topics: Substance Abuse

Print Friendly, PDF & Email

Daniel Carlat, MD

Opioid drugs represent one of the great triumphs of medicine, because they are extremely effective at relieving pain. Since the 1960s, multiple forms of synthetic opioids have been introduced, including such wellknown drugs as hydrocodone (Vicodin) and oxycodone (Percocet, Oxycontin). Unfortunately, the array of opiate options has led to an exponential rise in the abuse of prescription opiates, and a corresponding explosion of deaths due to opiate overdose. (For a good review of these issues, see Lanier W and Kharasch E, Mayo Clinic Proceedings 2009:84(7):572–575.) Equally unfortunate is that getting off of opiates is extremely difficult, and the best that many addicts can hope for is opioid maintenance, which is essentially trading one narcotic addiction for another.

For decades, methadone was the mainstay of opioid maintenance. Methadone has the advantage of being a very long acting oral opiate that can substitute well for street drugs such as IV heroin. And although methadone is effective for many patients, it poses problems. In order to prevent diversion of methadone, the federal government requires patients to visit federally-licensed methadone clinics daily—in effect handcuffing patients to a methadone clinic lifestyle. Patients with full-time jobs or those who want to travel or live in rural areas have a very hard time participating in methadone maintenance programs.

In 2002, the FDA approved Suboxone (sublingual buprenorphine/naloxone) for the treatment of opioid dependence. Suboxone revolutionized opioid maintenance treatment because it is less abusable than methadone, and therefore can be prescribed by physicians from their offices. The main ingredient in Suboxone is buprenorphine, a semisynthetic opioid that has been available as an injectable narcotic (brand name Buprenex) since 1981. Buprenorphine is a partial opioid agonist, meaning that it occupies the opiate receptors but doesn’t cause quite the same intensity of receptor activation (or “high”) as full opiate agonists such as oxycodone or methadone. The other ingredient in Suboxone is naloxone, which is an opiate blocker best known for emergency treatment of opioid overdose. Suboxone is composed of buprenorphine and naloxone in a ratio of 4:1.

Why, you might ask, would you combine an opiate antagonist with an opiate agonist? This is a neat pharmacological trick to prevent Suboxone from being ground up and shot intravenously. When taken as directed (sublingually), the buprenorphine works, but naloxone is poorly absorbed through the buccal mucosa and has only a minimal effect. However, when the tablets are crushed up and injected, naloxone comes alive, preventing the high and causing immediate withdrawal symptoms in patients addicted to opiates. Methadone, on the other hand, can be injected and will deliver a potent high, making it far more prone to abuse and diversion than Suboxone.

Although Suboxone has been shown to be superior to clonidine for opioid detoxification (Ziedonis DM et al., Drug Alcohol Depend 2009;99(1–3):28–36), its greatest strength lies in its FDA-approved use as an alternative to methadone for opioid maintenance therapy. A pivotal 52-week trial demonstrated Suboxone’s superiority to placebo in maintaining opioid-negative urine tests (Fudala PJ et al., N Engl J Med 2003;349(10):949–958); two randomized trials demonstrated non -inferiority to methadone maintenance therapy at 17 weeks and six months (Kakko J et al., Am J Psychiatry 2007;164(5):797–803); and clinical studies have shown effectiveness in maintaining sobriety in “real world” primary care settings (Cunningham C et al., Fam Med 2008;40(7):500–506).

Compared with methadone, Suboxone’s most obvious advantage is that it allows office-based maintenance treatment of opioid dependence. The difference in quality of life between patients on Suboxone versus methadone maintenance can be tremendous. Suboxone is also safer than methadone, since as a partial agonist, it is less likely to cause respiratory depression in overdose—although it can still cause significant sedation and respiratory depression when combined with benzodiazepines or other CNS depressants. Since Suboxone is still under patent, it is expensive, but because fewer office visits are needed, the overall cost of treatment is comparable to that of methadone maintenance (Doran CM, Expert Rev Pharmacoeconomics Outcomes Res 2005;5(5):583–591).

Although Suboxone theoretically is less abusable than other opiates, diversion and abuse of the drug have become extremely common. Because of this, the DEA tightly regulates its use. Physicians must complete an eight-hour CME course in order to obtain a special DEA number (known as a DATA 2000 waiver) before they can prescribe Suboxone. Even with the waiver, the DEA limits the number of patients on your Suboxone “panel” to a maximum of 30 during your first year of prescribing, and a maximum of 100 patients thereafter. (See the SAMSHA website at http://bit.ly/73fMfd for more information.)

So let’s assume you’ve attained your DATA 2000 waiver and are ready to prescribe Suboxone. Here’s how it’s typically done. The first phase of treatment is called the “induction.” Before a patient receives the first dose, he must be in opiate withdrawal. Why? Because if the patient has opiates in his system, Suboxone will bump the opiates off the binding sites and will precipitate a withdrawal—not a great way to foster the doctor patient alliance! As a rough rule of thumb, Oxycontin users should have taken their last dose no less than 24 hours before Suboxone to insure adequate withdrawal, and heroin users, about 12 hours. But to accurately assess the degree of withdrawal, you should use the Clinical Opiate Withdrawal Scale (COWS), which is available for free online at http://bit.ly/d0E9Ur. The scale will walk you through an assessment of the typical signs of opiate withdrawal, such as sweating, chills, yawning, muscle aches, nausea and vomiting.

Once your patient is clearly in withdrawal, you start by giving a 2 or 4 mg dose, then have the patient wait in the waiting room for an hour, and then reassess. If the withdrawal symptoms have disappeared, you have a good starting dose. If the symptoms have improved somewhat, you should give another 2 to 4 mg. And if the symptoms have worsened…well, then you’ve pretty much blown it because this means the patient was not in enough withdrawal at the beginning of the process. After you’ve estimated an adequate dose, you should see a patient daily for two or three days, then less often once you feel comfortable that he or she has been properly induced. Eventually, visit frequency is titrated down to monthly for most patients. A typical final target dose of Suboxone is in the range of 12 to 16 mg per day.

During each visit, the first thing to ask is: “Have you used?” because relapse to opiate abuse is common, as is abuse of other substances such as amphetamines, cocaine and benzodiazepines. Assess for signs of withdrawal at each visit, asking particularly about waking night sweats (which some patients may not realize is a symptoms of withdrawal), and about craving, which is often the “last stand” of the withdrawal syndrome and puts patients at high risk of relapse. If withdrawal symptoms occur, this generally means that the dose of Suboxone should be nudged higher.

Therapy during Suboxone visits should focus on identification and avoidance of triggers for drug use, support for efforts to get a job, and general encouragement to create as much structure in the patient’s life as possible. As you might imagine, many Suboxone patients have substantial psychiatric comorbidity, especially anxiety and mood disorders. While this could make treatment very complicated, most patients see a different psychiatrist for issues outside the realm of the addiction. “Farming out” treatment of comorbidities allows you to keep focused on the addiction while ensuring that patients still receive adequate treatment for other issues.

Because of the risk of diversion, working with Suboxone patients requires firm ground rules, and the dictum “I trust you, but I don’t trust your addiction” applies. Let patients know that there are no refills on their prescriptions, and if they miss an appointment, they will have to wait for another opening before they can get a new script. Most clinics require attendance at 12 step meetings, and require enrollment in a random urine drug testing program. Some states have a searchable database of all patients who have filled prescriptions for controlled substances, and looking up each patient every two or three months is a required safeguard to help detect doctor shopping. With all the hoops to jump through, you might find the idea of prescribing Suboxone daunting, but it can be fulfilling to work with this clientele, and for some practitioners it has become a lucrative practice model.

Suboxone Resources Suboxone Talk Zone (http://suboxonetalkzone.com) is a blog written by Jeffrey T Junig MD, PhD, a physician and recovering opiate addict. He sells an e-book on his blog called User’s Guide to Suboxone, which is a helpful handbook for both patients and prescribers. A standard Agreement for Treatment with Sublingual Buprenorphine/ Naloxone (Suboxone®) is available here. You are free to download and use this document in your own practice.

Josh Sonkiss, MD

Chief Resident University of Utah Department of Psychiatry

Dr. Sonkiss has disclosed that he has no relevant relationships or financial interests in any commercial company pertaining to this educational activity.

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  • Update on Eating Disorders (October)
  • Complex Psychopharmacology (September)
  • Laboratory Testing in Psychiatry (August)
  • Psychotherapy in Psychiatry (July)
  • Posttraumatic Stress Disorder (June)
  • Topics in Geriatric Psychiatry 2007 (May)
  • Pregnancy and Menopause in Psychiatry (Apil)
  • Antipsychotic Roundup 2007 (March)
  • Understanding Psychiatric Research (February)
  • Antidepressant Round-up 2007 (January)

2006

  • Technology and Psychiatric Practice (December)
  • The Use of MAOIs (November)
  • Medication Treatment of Depression (January)
  • Seasonal Affective Disorder (October)
  • Treatment of ADHD (September)
  • Topics in Bipolar Disorder (August)
  • Neurotransmitters in Psychiatry (July)
  • Treating Substance Abuse (June)
  • The STAR*D Antidepressant Trial (May)
  • Natural Treatments in Psychiatry (April)
  • Medication Treatment of Anxiety (March)
  • Panic Disorder: Making Treatment Work (March)
  • Antipsychotic Roundup 2006 (February)
  • Antidepressant Roundup 2006 (January)

2005

  • Self-Help Books and Psychiatry (December)
  • Genetics and Psychiatry (November)
  • Pregnancy and Psychiatric Treatment (October)
  • Benzodiazepines and Hypnotics in Psychiatry (September)
  • Geriatric Psychiatry Update (August)
  • Chart Documentation in Psychiatry (July)
  • The Treatment of Bipolar Disorder (June)
  • Weight Loss and Smoking Cessation in Psychiatry (May)
  • Treating ADHD (April)
  • Drug Industry Influence in Psychiatry (March)
  • Atypical Antipsychotics 2005 (February)
  • Antidepressant Roundup 2005 (January)

2004

  • Sexual Dysfunction (December)
  • Suicide Prevention (November)
  • To Sleep, To Awake (October)
  • Women’s Issues in Psychiatry (September)
  • OCD: An Update (August)
  • Chronic Pain and Psychiatry (July)
  • Neuroimaging in Psychiatry (June)
  • Natural Medications in Psychiatry (May)
  • Posttraumatic Stress Disorder (April)
  • Treatment of Alcoholism (March)
  • Battle of the Atypicals (February)
  • Antidepressant Roundup, 2004 (January)

2003

  • Research Methods in Psychiatry (December)
  • Antidepressants in Children (November)
  • The Treatment of Dementia (October)
  • Bipolar Disorder, Part II: The Novel Anticonvulsants (September)
  • Bipolar Disorder: The Basics (August)
  • Drug-Drug Interactions in Psychiatry (July)
  • Managing Antidepressant Side Effects (June)
  • Antidepressants in Pregnancy and Lactation (May)
  • ADHD: Medication Options (April)
  • Panic Disorder: Making Treatment Work (March)
  • Atypical Antipsychotics in Clinical Practice (February)
  • Medication Treatment of Depression (January)

2019

  • Autism in Children and Adolescents (November/December)
  • Depression in Children and Adolescents (May/June/July/August)
  • Substance Use in Children and Adolescents (September/October)
  • Trauma in Children and Adolescents (March/April)
  • Anxiety in Children and Adolescents (January/February)

2018

  • Psychotropic Risks in Children and Adolescents (May/June)
  • ADHD in Children and Adolescents (November/December)
  • Depression in Children and Adolescents (September/October)
  • Autism in Children and Adolescents (July/August)
  • Anxiety in Children and Adolescents (March/April)
  • Suicide in Children and Adolescents (January/February)

2017

  • Adolescents (November/December)
  • ADHD in Children and Adolescents (September/October)
  • Psychosis in Children and Adolescents (August)
  • PANDAS, PANS, and Related Disorders (June/July)
  • Marijuana in Children and Adolescents (May)
  • Tourette’s and Other Tic Disorders in Children and Adolescents (March/April)
  • Autism in Children and Adolescents (January/February)

2016

  • Gender Dysphoria in Children and Adolescents (November/December)
  • Technology Issues With Children and Adolescents (September/October)
  • Mood Dysregulation in Children and Adolescents (July/August)
  • Eating Disorders in Children and Adolescents (May/June)
  • Conduct Disorder in Children and Adolescents (April)
  • Sleep Disorders in Children and Adolescents (March)
  • ADHD in Children and Adolescents (January/February)

2015

  • Antidepressant Use in Children (November/December)
  • Foster Care and Child Psychiatry (September/October)
  • Autism (July/August)
  • Trauma (May/June)
  • Anxiety Disorders (April)
  • Schools and Psychiatry (March)
  • Emergency Psychiatry in Children (January/February)

2014

  • Antipsychotics in Children (December)
  • ADHD (November)
  • Gender and Sexuality (September/October)
  • Psychotic Symptoms (Summer)
  • Medication Side Effects (May)
  • Food and Mood (April)
  • Learning and Developmental Disabilities (February)

2013

  • Complex Practice Issues (December)
  • Diet and Nutrition (November)
  • Child Psychiatry in DSM-5 (August/September)
  • Medication Side Effects and Interactions (June/July)
  • Problematic Technology (March/April)
  • Autism Spectrum Disorders (January/February)

2012

  • Bipolar Disorder (December)
  • Substance Abuse (October/November)
  • Transitional Age Youth (July/August)
  • Rating Scales (May/June)
  • Eating Disorders (March/April)
  • Behavioral Disorders (February)

2011

  • Treatment of Anxiety Disorders (December)
  • Trauma (November)
  • Bullying and School Issues (October)
  • Hidden Medical Disorders (August)
  • OCD and Tic Disorders (June)
  • Suicide and Non-Suicidal Self Injury (April)
  • Sleep Disorders (March)
  • ADHD (January)

2010

  • Use of Antipsychotics in Children and Adolescents (December)
  • Learning and Developmental Disabilities (October)
  • Major Depression (September)
  • Treating Children and Families (July)
  • The Explosive Child (May)

2019

  • Dual Diagnosis in Addiction Medicine (May/June)
  • Medical Issues in Addiction Practice (November/December)
  • Alcohol Addiction (September/October)
  • Legal Issues in Addiction Medicine (July/August)
  • Traumatic Brain Injury and Addiction (March/April)
  • Board Certification in Addiction Medicine (January/February)

2018

  • Opioid Addiction (November/December)
  • Addiction in Older Adults (October)
  • Sleep Disorders and Addiction (September)
  • Adolescent Addiction (July/August)
  • Pain and Addiction (May/June)
  • Cannabis and Addiction (March/April)
  • Stigma and Addiction (January/February)

2017

  • Pregnancy and Addiction (November/December)
  • Detox (Sepember/October)
  • Dual Diagnosis (August)
  • Alternatives to 12-Step Programs (June/July)
  • Recovery (May)
  • Psychiatric Uses of Street Drugs (March/April)
  • Sex Addiction (January/February)

2016

  • Prescription Drug Monitoring Programs (PDMPs) (November/December)
  • Addiction in Health Care Professionals (September/October)
  • Dialectical Behavior Therapy in Addiction (August)
  • Motivational Interviewing (June/July)
  • Benzodiazepines (May)
  • Opioid Addiction (March/April)
  • Families and Substance Abuse (January/February)

2015

  • The Twelve Steps (November/December)
  • Designer Drugs (September/October)
  • Residential Treatment Programs Decoded (July/August)
  • Nicotine and E-Cigarettes (June)
  • Drug Screening (April/May)
  • Integrating Therapy and Medications for Alcoholism (March)
  • Detoxification Protocols (January/February)

2014

  • Behavioral Addictions (December)
  • Risk and Reimbursement (November)
  • Stimulant Abuse (September/October)
  • Self-Help Programs (June)
  • Opioid Addiction (May)
  • Coping with Bad Outcomes (March)
  • Change Management in Addiction Treatment (January/February)

2013

  • Cocaine Addiction (December)
  • Relapse Prevention (November)
  • Cannabis Addiction (August/September)
  • Addiction in DSM-5 (June/July)
Editor-in-Chief

Chris Aiken, MD

Dr. Aiken is the director of the Mood Treatment Center in North Carolina, where he maintains a private practice combining medication and therapy along with evidence-based complementary and alternative treatments. He has worked as a research assistant at the NIMH and a sub-investigator on clinical trials, and conducts research on a shoestring budget out of his private practice.

Full Editorial Information

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