Tricyclic Antidepressants: When and How to Use Them
The Carlat Psychiatry Report, Volume 20, Number 5, May 2022
Edmund S. Higgins, MD. Clinical associate professor, Psychiatry and Behavioral Sciences, Medical University of South Carolina.
Dr. Higgins has disclosed no relevant financial or other interests in any commercial companies pertaining to this educational activity.
Tricyclics have been used in psychiatry since the 1950s, when imipramine was introduced as the first mass-marketed antidepressant. Fluoxetine and the other SSRIs largely supplanted the tricyclics in the 1990s, but these medications still have their uses.