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Home » Highlights From This Issue

Highlights From This Issue

February 10, 2020
From The Carlat Psychiatry Report
Issue Links: Learning Objectives | Editorial Information | PDF of Issue

  • Inflammation contributes to treatment resistance in depression and can be measured with a blood test, C-reactive protein (CRP).

  • An elevated CRP predicts a favorable response to certain antidepressants, as well as specific lifestyle interventions.

  • Nuedexta’s expanded use in dementia is based on questionable efficacy, but it is safer than many of the psychotropics routinely used in that population. It’s expensive, but there are ways to prescribe a generic equivalent.


Price Drop on L-methylfolate. In our August 2019 issue, we compared two supplements that are used to augment antidepressants: folate (0.5 mg to 10 mg/day) and l-methylfolate (15 mg/day). The clinical data pointed toward l-methylfolate, but the price of this supplement put it out of reach for many patients. We’ve since become aware of a more affordable version of l-methylfolate that’s within the price range of folate. Opti-folate 15 mg is $13/month on Amazon.
General Psychiatry
KEYWORDS depression dopamine exercise inflammation mood disorders nutrition psychosomatics
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    Issue Date: February 10, 2020
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    Table Of Contents
    Highlights From This Issue
    An Answer for Psychotic Depression
    Nuedexta in Agitated Dementia
    Inflammatory Biomarkers in Depression
    How to Use Pramipexole
    Polypharmacy in Schizophrenia
    CME Post-Test - Inflammation and Depression, TCPR, February 2020
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