Folic acid and l-methylfolate are two versions of the same vitamin. Both are popular for antidepressant augmentation, but one is a expensive prescription. We compared them side-by-side and found that one has a slight advantage.

Dr. Mago reveals his top strategies for common side effects. Featuring safe-dosing of metformin, vitamins for hair loss, and special stockings for orthostasis.

With Vrylar’s new approval, there are now four atypicals antipsychotics with an indication in bipolar depression. Only two of these, however, are known to work in mania as well as depression. None of the atypicals stands out as the perfect choice for bipolar depression, but there are pros and cons to each that make them fitter better with certain patients.

Recent trials cast doubt on prazosin’s role in PTSD, but there are reasons to doubt their results.

After reading these articles, you should be able to…

The post-test for this issue is available for one year after the publication date to subscribers. By successfully completing the test you will be awarded a certificate for 1 CME credit.

On March 5, 2019, the FDA approved esketamine (Spravato) nasal spray as add-on therapy to traditional antidepressant medications for treatment-resistant depression (TRD). In this article, I will describe the events that led to esketamine’s development, review the data submitted to the FDA, and discuss what the future might hold for esketamine.

Certain psychiatric treatments require both the healthcare provider and patient to enroll in a Risk Evaluation and Mitigation Strategy (REMS) program before they are administered. Here are links to enroll.

Does ginger ale treat nausea? Not really, but Dr. Mago has some better ideas, and this interview is packed with new and practical ways to manage common side effects of psychiatric medications.

When a patient presents with auditory hallucinations (AH), are you likely to diagnose a psychotic disorder? If no other symptoms are present, would you recommend an antipsychotic? If you answered yes to either question, there’s some new research that may change your mind.