Depression - Page 1 | CARLAT PUBLISHING

Gender Affirming Care: Fall of the House of Hopkins

May 18, 2026

Chris Aiken, MD and Kellie Newsome, PMHNP

In 1966, Johns Hopkins opened the first gender surgery clinic in the US. Thirteen years later, a single study shut it down. We examine what the research said, what it didn't say, and how new standards of care emerged from the ashes.

Gender Affirming Care in Exile: Targeting the Leader

May 11, 2026

Chris Aiken, MD and Kellie Newsome, PMHNP

The president of the US branch of WPATH built one of the largest youth gender clinics in the country, then watched it close under political fire. Now she's facing a malpractice lawsuit from a former patient. We examine the unpublished study at the center of the controversy.

Gender Affirming Care in Exile: The Trials

May 4, 2026

Chris Aiken, MD and Kellie Newsome, PMHNP

Medical societies are reversing decades of support for gender-affirming care in youth — but is it the science driving the shift, or the politics? This episode walks through the evidence, from randomized trials to regret rates, and finds a more complicated picture than either side presents.

Gender Affirming Care in Exile: The Lawsuits

April 27, 2026

Chris Aiken, MD and Kellie Newsome, PMHNP

Two malpractice cases — one worth $2 million — are reshaping the standards of gender-affirming care. This episode traces what went wrong, what held up in court, and what every clinician needs to know when referring patients for gender affirming procedures.

Fact Sheet

Depression in Pregnancy: Diagnosis and Treatment

April 24, 2026

Victoria Hendrick, MD and Daniel Carlat, MD

Dr. Hendrick and Dr. Carlat have no financial relationships with companies related to this material.
Full Fact Sheet Editorial Information

Prenatal depression is common, affecting 10%–15% of pregnant patients.

Research Update

Lumateperone Eases Depression With Mixed Features

April 1, 2026

Alla Alexander, MD

Alla Alexander, MD. Dr. Alexander has no financial relationships with companies related to this material.

A new placebo-controlled trial suggests lumateperone rapidly improves depressive and manic symptoms in mixed features—with minimal metabolic or EPS burden.

Hidden Gems: Pramipexole Part II

March 2, 2026

Chris Aiken, MD and Kellie Newsome, PMHNP

Pramipexole has moved up the in our algorithm for treatment resistant depression. Today, learn how to use this dopamine agonist.

Hidden Gems: Pramipexole Part I

February 23, 2026

Chris Aiken, MD and Kellie Newsome, PMHNP

New research moves pramipexole up in the algorithm for treatment resistant depression.

ProLivRx: How it Works

January 26, 2026

Chris Aiken, MD and Kellie Newsome, PMHNP

How a new FDA approved device for difficult-to-treat depression engages the brain through the sensory nerves in part II of our interview with Linda Carpenter.