Is Clozapine the Next Step After a Single Failed Antipsychotic Trial?
The Carlat Psychiatry Report, Volume 16, Number 11 & 12, November 2018
Xavier Preud’homme, MD
Dr. Preud’homme has disclosed that he has no relevant financial or other interests in any commercial companies pertaining to this educational activity.
Clozapine is often used as a last resort in schizophrenia, even though practice guidelines recommend a trial of this medication after failing 2 antipsychotics. The current study set out to test a treatment algorithm based on those guidelines in patients with first-episode psychosis.