Outdoor activity, massage, and touch therapy ranked most effective for agitation in dementia.
In a meta-analysis of 163 randomized controlled trials, nonpharmacologic interventions were more effective than antipsychotics for aggression and agitation in dementia (Watt JA, Ann Intern Med 2019 Oct 15).
Risperidone doesn’t appear to cause fractures.
Risperidone did not increase the risk of fractures any more than other antipsychotics in a cohort study of 116,000 patients who were given a new prescription of any antipsychotic and filled it at least twice. There had been theoretical concerns about fractures on risperidone because it has a high rate of elevated prolactin (80%–90%), which in turn raises the risk of osteopenia. These reassuring results are in line with earlier clinical studies (Clapham E et al, Acta Psychiatr Scand 2019 Sep 23).
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