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Home » Stimulants as Cognitive Enhancers

Stimulants as Cognitive Enhancers

November 15, 2019
Chris Aiken, MD.
From The Carlat Psychiatry Report
Issue Links: Learning Objectives | Editorial Information | PDF of Issue
Chris Aiken, MD. Editor-in-Chief of The Carlat Psychiatry Report.
Depending on your practice setting, you are likely to encounter adults who seek stimulants for various “non-medical” uses, from cognitive enhancement to recreational abuse to outright diversion.

Abuse and diversion are easier to detect these days with the controlled substance databases available in most states. Abuse of stimulants is relatively rare. Over 90% of recreational stimulant users do not meet DSM-5 criteria for abuse (Arria AM and DuPont RL, Am J Psychiatry 2018;175(8):707–708). Instead, many are using them to enhance their cognitive performance. This kind of “cosmetic psychopharmacology” is so common in the college years (20%–30% of students) that stimulant prescriptions are banned or severely restricted at many college mental health centers.


High-achieving adults are also at risk. When the journal Nature polled its readers anonymously, 1 in 5 were taking non-prescribed stimulants to enhance their focus, memory, and concentration (Maher B, Nature 2008;452(7188):674–675). Elvis Presley, John F. Kennedy, and Hugh Hefner all took stimulants to enhance their performance. Kennedy and Hefner stopped when their associates noticed signs of irritability and paranoia, but the King’s use went largely unchecked and may have contributed to his erratic behavior in the 1970s.


Contrary to popular belief, stimulants do not always improve mental functioning in healthy individuals. Overall, meta-analyses have failed to support a significant improvement, although they do appear to work in situations that require sustained attention to boring, repetitive tasks. Stimulants can also reverse some of the effects of sleep deprivation, but a new placebo-controlled study suggests they may impair cognition by disrupting sleep the next day. A single dose of dextroamphetamine 20 mg was enough to impair sleep and, on the day after, working memory, even when given as an instant release in the morning (Tselha T et al, Behav Brain Res 2019;370:111940).


More concerning are the long-term risks of stimulants when used outside of ADHD. Their abuse potential and cardiovascular risks are well known. Rarely, they can cause psychosis, and in high doses they have neurotoxic effects, causing apoptosis (ie, cell death) in the brain. Both of these risks are greater with the amphetamines (eg, Adderall and Vyvanse) than the methylphenidates (eg, Ritalin, Focalin, Concerta) (He W et al, Neurotox Res 2018;34(2):233–240; Moran LV et al, N Engl J Med 2019;380(12):1128–1138).


General Psychiatry
KEYWORDS adhd amphetamines attention-deficit-hyperactivity-disorder cognition cosmetic-pharmacology methylphenidate
    Aiken
    Chris Aiken, MD.

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    www.thecarlatreport.com
    Issue Date: November 15, 2019
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    Table Of Contents
    CME Post-Test - Adult ADHD, TCPR, November/December 2019
    Highlights From This Issue
    Adult-Onset ADHD
    Micronutrients in Mental Health
    Adult ADHD: What Else Could It Be?
    Stimulants as Cognitive Enhancers
    A Practical Guide to Light Therapy
    Meet the First H3 Antagonist
    An Antipsychotic Patch
    Pharmacology for GAD: Complex Choices
    Olanzapine for Anorexia Nervosa
    In Brief: Antipsychotic Update
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