Schizophrenia - Articles | CARLAT PUBLISHING

CLINICAL UPDATE

Generic Lurasidone Shifts the Balance in Bipolar Depression

June 12, 2025

Chris Aiken, MD. Editor-in-Chief, The Carlat Psychiatry Report. Assistant Professor, NYU Langone Department of Psychiatry. Practicing psychiatrist, Winston-Salem, NC.

Dr. Aiken has no financial relationships with companies related to this material.

Lurasidone was heralded as a game changer when it first gained FDA approval for bipolar depression in 2013. In 2023, this article covers what that means for patients with bipolar disorder and schizophrenia who can now afford its $10–$20/month cost.

EXPERT Q&A

A Clozapine Primer

June 12, 2025

Jonathan G. Leung, PharmD, RPh, Clinical pharmacist specialist, Mayo Clinic, Rochester, MN. Associate Professor of Pharmacy and Associate Professor of Psychiatry, Mayo Clinic, College of Medicine and Science.

Dr. Leung has no financial relationships with companies related to this material.

There are over 20 antipsychotics, so which one do you start with? Dr. Leung, who helped start a clozapine clinic gives us a primer on Clozapine.

ECT in Clozapine-Resistant Schizophrenia

May 1, 2025

Simon M. Dosovitz, MD

Simon M. Dosovitz, MD.

Dr. Dosovitz has no financial relationships with companies related to this material.

It’s difficult to find options when clozapine does not work.

Expert Q&A

Sorting Out Psychotic-Like Experiences in Children and Teens

April 1, 2025

Kristin Cadenhead, MD

Kristin Cadenhead, MD, Professor of psychiatry, director of Cognitive Assessment and Risk Evaluation (CARE) early psychosis research and treatment program, University of California San Diego, San Diego, CA.

Dr. Cadenhead has no financial relationships with companies related to this material.

What are psychotic-like experiences (PLE) in children and teens, and what is the prognosis for those who have them? Should we treat immediately with antipsychotics? Watch and wait? Our interview with Dr. Kristin Cadenhead gives you the guidance you need to assess and manage PLE.

How Soon Is Soon Enough When Predicting Antipsychotic Nonresponse?

April 1, 2025

Alaina Burns, MD

Alaina Burns, MD. Dr. Burns has no financial relationships with companies related to this material.

How long should we wait before changing an antipsychotic that doesn’t seem to be working? A large multicenter study finds that minimal symptom improvement by weeks two to four strongly predicts treatment failure and suggests an earlier switch can improve outcomes in schizophrenia.

Precision in Psychiatry: Diagnosing, Treating, and Differentiating Core Psychiatric Conditions

November 11, 2024

Mark L. Ruffalo, MSW, DPsa and Nassir Ghaemi, M.D.

Today, we delve into the complicated world of psychiatric diagnoses and their impact on treatment.

Research Update

Estrogen in Schizophrenia

November 1, 2024

Sarah Azarchi, MD

Sarah Azarchi, MD. Dr. Azarchi has no financial relationships with companies related to this material.

Estrogen therapy may improve schizophrenia symptoms in women, highlighting its potential role as an adjunctive treatment.

KarXT (Cobenfy): The Breakthrough Antipsychotic That Could Change Everything

October 18, 2024

Jason Mallo, DO and Greg Malzberg, MD

In this video, we take an in-depth look at the recently FDA-approved antipsychotic, KarXT, also known by its brand name Cobenfy. This new drug represents a major breakthrough in schizophrenia treatment because, unlike traditional antipsychotics, it doesn’t rely on blocking dopamine receptors. Instead, KarXT works through a muscarinic agonist mechanism, making it a completely different approach to managing schizophrenia and other psychotic disorders.

Research Update

How Long to Wait Before Changing Antipsychotics in Schizophrenia?

October 1, 2024

Lara Tang, MD

Lara Tang, MD. Dr. Tang has no financial relationships with companies related to this material.

How long should you wait before making changes after initiating an antipsychotic? The current study tested if early efficacy on an antipsychotic predicts subsequent efficacy, and its findings indicate benefits may be observed as quickly as two weeks.

Research Update