Depression - Articles - Page 17

Esketamine Gets FDA Approval

July 3, 2019

Michael Posternak, MD. Psychiatrist in private practice, Boston, MA. Dr. Posternak has disclosed that he has no relevant financial or other interests in any commercial companies pertaining to this educational activity.

On March 5, 2019, the FDA approved esketamine (Spravato) nasal spray as add-on therapy to traditional antidepressant medications for treatment-resistant depression (TRD). In this article, I will describe the events that led to esketamine’s development, review the data submitted to the FDA, and discuss what the future might hold for esketamine.

Risk Evaluation and Mitigation Strategy (REMS) Programs

July 3, 2019

Certain psychiatric treatments require both the healthcare provider and patient to enroll in a Risk Evaluation and Mitigation Strategy (REMS) program before they are administered. Here are links to enroll.

Brexanolone (Zulresso) for Postpartum Depression

July 3, 2019

Talia Puzantian, Chris Aiken, MD, and Chris Aiken

Talia Puzantian, PharmD, BCPP Chris Aiken, MD Drs. Puzantian and Aiken have disclosed that they have no relevant financial or other interests in any commercial companies pertaining to this educational activity.

Every week of depression takes a toll on infant development, so this rapid-acting treatment fills a unique need. Here we review the clinical data and the pragmatics of getting patients connected with the therapy.

Lithium in Geriatric Depression

July 3, 2019

Jason Mallo, DO

Jason Mallo, DO Dr. Mallo has disclosed that he has no relevant financial or other interests in any commercial companies pertaining to this educational activity.

Lithium is underutilized in geriatric depression, but this study suggests it may have unique benefits there.

How to Use Amantadine

June 24, 2019

Rarely used but often studied, amantadine is a medicine that doesn't fit neatly into any boxes. It's thought to work in OCD, autism, depression, cognition, ADHD, weight loss, sexual dysfunction, and traumatic brain injury. But how good is that research, and when should you use it? Chris Aiken and Kellie...

Transcranial Magnetic Stimulation (TMS) for Depression in Children and Adolescents

June 11, 2019

With concerns about both safety and efficacy surrounding antidepressant use in children and adolescents, we are always looking for safe, effective treatments for our patients. Transcranial Stimulation (TMS) has been around for many years, and its use in youth is expanding. We examine the evidence of efficacy and potential side effects in youth and adolescent populations.

Medications for Depression

June 11, 2019

Martha J. Ignaszewski, MD

Martha J. Ignaszewski, MD

Chief Fellow, Clinical Fellow in Psychiatry at Boston Children’s Hospital

Dr. Ignaszewski has disclosed that she has no relevant financial or other interests in any commercial companies pertaining to this educational activity.

In this QA, we review the findings of placebo- controlled trials done over the past 10 years on depression in kids and the discuss the current recommendations for medication treatment of depression in children and adolescents.

An Antidepressant Diet With Felice Jacka, MD

June 3, 2019

A healthy diet is associated with an approximately 30% reduction in the risk for depression and a 40% improvement in cognition. That’s after controlling for education, income, other health behaviors, and body weight. This podcast discusses a recent interview with Felice Jacka, MD, Professor at Deakin University, Geelong, Victoria, Australia.

An Antidepressant Diet

May 8, 2019

Felice Jacka, MD

Felice Jacka, MD Professor at Deakin University, Geelong, Victoria, Australia. Director, Food and Mood Centre. Founder and President, International Society for Nutritional Psychiatry Research. Dr. Jacka has disclosed that she has no relevant financial or other interests in any commercial companies pertaining to this educational activity.

We have a decade of observational evidence linking the quality of people’s diets to their risk for depression. Those findings were pretty consistent across countries, cultures, and age groups: A healthy diet is associated with an approximately 30% reduction in the risk for depression and a 40% improvement in cognition.

An Opioid Combo Falls Short in Depression

February 1, 2019

Chris Aiken, MD

Chris Aiken, MD.
Editor-in-Chief of The Carlat Psychiatry Report. Practicing psychiatrist, Winston-Salem, NC. Dr. Aiken has disclosed that he has no relevant financial or other interests in any commercial companies pertaining to this educational activity.

Opioids have a bad name these days. But let’s not forget that they were once considered a first-line treatment for depression before the discovery of MAOIs and tricyclics in the 1950s. That history has been revived recently by buprenorphine, a partial opioid agonist that was fast-tracked by the FDA for treatment-resistant depression.