We may think of clozapine as a drug of the ‘90s, but Sandoz began research on the drug in the early ‘60s, and the first paper appeared in 1966, the Medical Journal of Vienna.

I know what you're thinking, "This is going to be a Cymbalta vs. Effexor article, and Cymbalta will get another TCR drubbing as it did last year." Not quite. In fact, there are two major battles to be reviewed: Effexor vs. Cymbalta, but probably more relevant, Effexor vs. Lexapro.

The notion that passing magnets over people's heads could make them happier has been around for a very, very long time, at least since the 1770s. The Viennese physician Franz Anton Mesmer used the technique in front of large 18th century audiences, and was so successful that Louis XVI funded the establishment of a "Magnetic Institute" in France to work on the technique further.

Very quietly, under our very noses, most of the newer antidepressants have gone generic, the latest being Celexa (citalopram). Before more details, here is a little generics review for those of you who have not been keeping up with this ferociously litigious area of psychopharmacology.

Dr. Gitlin, to begin with, my readers would be interested in your impressions of the new kid on the block, Cymbalta (duloxetine).

Eight or nine years ago I had a couple of young adults become highly agitated and violent in the week after I started an SSRI (paroxetine in both cases). One beat up his girlfriend badly despite the lack of any history of violence previously.

When Prozac first appeared, it was a wonder drug--effective, well-tolerated, and safe in overdose. And, said Eli Lilly, only 1.9% of patients in the clinical trials suffered sexual dysfunction as a side effect. Clinicians weren't so sure about that figure.

Anybody who watched the recent World Series between the Red Sox and the Cardinals got a pretty good education in Viagrology, Levitrology, and Cialisology. Between footage of men shopping at Victoria's Secret and couples soaking in outdoor tubs, it was a challenge to fit in a few double plays and home runs.

Marlene Dietrich once observed that "in America sex is an obsession, in other parts of the world it is a fact." While that may be true, sex is never terribly easy to discuss, no matter what your longitude and latitude.

Index to The Carlat Report Volume 2, 2004.