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Home » Topics » General Psychiatry

General Psychiatry
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The Father of Bipolar Disorder

September 1, 2003
From The Carlat Psychiatry Report
Issue Links: Editorial Information | PDF of Issue
In the late 1800’s, the German psychiatrist Emil Kraepelin was unhappy with the primitive state of psychiatric diagnosis. So he set up shop at the Heidelberg Clinic and proceeded to study hundreds of patients longitudinally.
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Bipolar Confusion: Diagnosis Hints

August 1, 2003
Daniel Carlat, MD
From The Carlat Psychiatry Report
Issue Links: Editorial Information | PDF of Issue
Daniel Carlat, MD Dr. Carlat has disclosed that he has no significant relationships with or financial interests in any commercial companies pertaining to this educational activity.
Suddenly, it seems that everybody and their cousin is asking us if they have bipolar disorder. A few years ago, bipolar disorder was the ignored orphan diagnosis in psychiatry. However, now that various patented molecules have been proven effective, industry money is flying into efforts to publicize the diagnosis, and it's clearly working.
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The Incredible, The Amazing, Lithium

August 1, 2003
Daniel Carlat, MD
From The Carlat Psychiatry Report
Issue Links: Editorial Information | PDF of Issue
Daniel Carlat, MD Dr. Carlat has disclosed that he has no significant relationships with or financial interests in any commercial companies pertaining to this educational activity.
It's an amazing metal. Not only does it treat acute mania, prevent recurrences, and treat refractory depression, but when consumed as LiCl, it tastes pretty good on vegetables. Or at least it did before the 1950s, when it was dropped from the list of acceptable salt-substitutes for hypertensives because of a nasty tendency to cause toxicity.
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The Lowdown on Depakote

August 1, 2003
Daniel Carlat, MD
From The Carlat Psychiatry Report
Issue Links: Editorial Information | PDF of Issue
Daniel Carlat, MD Dr. Carlat has disclosed that he has no significant relationships with or financial interests in any commercial companies pertaining to this educational activity.
First thing's first. What's the deal with all the confusing names for Depakote? The basic, irreducible molecule here is valproic acid, also known as valproate, and the brand name of this is "Depakene", not Depakote.
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Dr. Nassir Ghaemi on Antidepressants in Bipolar Disorder

August 1, 2003
Nassir Ghaemi, M.D.
From The Carlat Psychiatry Report
Issue Links: Editorial Information | PDF of Issue
Nassir Ghaemi, M.D.Nassir Ghaemi, M.D. Assistant Professor of Psychiatry at Harvard Medical School Director of Bipolar Disorders Research Program, Cambridge Hospital, Cambridge, MA Author, Mood Disorders: A Practical Guide



Dr. Ghaemi, I thought we could discuss this rather controversial issue of whether antidepressants (ADs) should be prescribed in bipolar disorder, particularly in light of the recent article published in the American Journal of Psychiatry by Altshuler et. al. (1).
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The Lithium Story

August 1, 2003
From The Carlat Psychiatry Report
Issue Links: Editorial Information | PDF of Issue
The discovery of the therapeutic effects of lithium is one of the most fabulous examples of serendipity in all of science. In 1949, John Cade was a 37 year old superintendent of a psychiatric hospital in the Australian outback.
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Cyclothymia

August 1, 2003
From The Carlat Psychiatry Report
Issue Links: Editorial Information | PDF of Issue
Dr. Carol Edelstein is a psychiatrist in private practice in Los Angeles, California, and has a particular interest in eating disorders. She describes a case below that falls in that vague hinterland between cyclothymia and bipolar disorder, type II.
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A Basic Course in Drug Metabolism

July 1, 2003
Daniel Carlat, MD
From The Carlat Psychiatry Report
Issue Links: Editorial Information | PDF of Issue
Daniel Carlat, MD Dr. Carlat has disclosed that he has no significant relationships with or financial interests in any commercial companies pertaining to this educational activity.
We apologize in advance. But it was inevitable that TCR would eventually have to tackle what may be the most boring topic in all of psychiatry, if not medicine in general: Drug-drug interactions.
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Drug-Drug Interactions You Need to Know

July 1, 2003
Daniel Carlat, MD
From The Carlat Psychiatry Report
Issue Links: Editorial Information | PDF of Issue
Daniel Carlat, MD Dr. Carlat has disclosed that he has no significant relationships with or financial interests in any commercial companies pertaining to this educational activity.
Drug interactions are enormously complicated. In tried and true TCR fashion, I have tried to make this topic easier to stomach. Nonetheless, you can skip this article if you make a decision to avoid prescribing the following medications ...
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What to Remember about Lithium

July 1, 2003
Daniel Carlat, MD
From The Carlat Psychiatry Report
Issue Links: Editorial Information | PDF of Issue
Daniel Carlat, MD Dr. Carlat has disclosed that he has no significant relationships with or financial interests in any commercial companies pertaining to this educational activity.
When it comes to Lithium, you can (thankfully) forget all about the P450 enzymes, because they don't touch this salt. Lithium enters the bloodstream, accomplishes its mysterious mood-stabilizing duties, and then is simply whisked out of the body intact by the kidneys via urine. So with Lithium, it's all about kidneys.
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