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You’re sitting with a patient. They’re worried about weight gain.

August 1, 2025

You’re sitting with a patient.

They’ve had terrible luck with sexual side effects.
And you’re silently trying to recall which SSRI is "less bad" on GI issues.
It’s not that you don’t know the data—it’s that it’s never all in one place.

The Strange Side of Antidepressants

Fun facts from the upcoming Medication Fact Book, 8th Edition

May 23, 2025

Daniel Carlat, MD

SSRIs and Intracerebral Hemorrhage Risk

May 21, 2021

Paul Barkopoulos, MD.

Paul Barkopoulos, MD. Dr. Barkopoulos has disclosed no relevant financial or other interests in any commercial companies pertaining to this educational activity.

SSRIs help relieve post-stroke depression but increase the risk of intracerebral hemorrhage. This study gives us tips to reduce this risk.

Can Antidepressants Prolong Survival in Cancer Patients?

May 21, 2021

Paul Barkopoulos, MD.

Paul Barkopoulos, MD. Dr. Barkopoulos has disclosed no relevant financial or other interests in any commercial companies pertaining to this educational activity.

Antidepressant adherence is linked with increased survival among cancer patients.

Optimal Antidepressant Doses in Major Depression

March 9, 2020

Kristen Gardner, PharmD.

Kristen Gardner, PharmD. Dr. Gardner has disclosed that she has no relevant financial or other interests in any commercial companies pertaining to this educational activity.

More is not necessarily better in psychopharmacology. Some medications have plateau effect, while others follow a “U-shaped curve,” causing more problems as the dose goes too high. This metaanalysis looked at 77 dose-response trials with antidepressants to quantify their optimal therapeutic window.