It’s difficult to find options when clozapine does not work.

Estrogen therapy may improve schizophrenia symptoms in women, highlighting its potential role as an adjunctive treatment.

How long should you wait before making changes after initiating an antipsychotic? The current study tested if early efficacy on an antipsychotic predicts subsequent efficacy, and its findings indicate benefits may be observed as quickly as two weeks. 

Conventional wisdom suggests that antipsychotics need similar doses for mania and schizophrenia. This analysis clarifies the exceptions.

Incorporating a simple and low-cost intervention—aerobic exercise—into cognitive rehabilitation programs for patients with schizophrenia accelerates cognitive gains and improves school and work functioning.

The findings of this large study offer some reassurance about the safety and efficacy of antipsychotic polypharmacy, despite general treatment guidelines cautioning against it.

This comprehensive study highlights the need for gender-specific treatment in schizophrenia spectrum disorders, revealing that hormonal changes call for lower antipsychotic doses for female patients under 45 and higher doses for those who are post-menopausal.