• Home
  • Store
    • Newsletter Subscriptions
    • Multimedia Subscriptions
    • Books
    • eBooks
    • ABPN SA Courses
  • CME Center
  • Multimedia
    • Podcast
    • Webinars
    • Blog
  • Newsletters
    • General Psychiatry
    • Child Psychiatry
    • Addiction Treatment
    • Hospital Psychiatry
    • Geriatric Psychiatry
  • Log In
  • Register
  • Welcome
  • Sign Out
  • Subscribe
Home » Treating Agitation in ICU Patients with AUD?

Treating Agitation in ICU Patients with AUD?

May 1, 2022
Jedidiah Perdue, MD, MPH
From The Carlat Addiction Treatment Report
Issue Links: Editorial Information | PDF of Issue

Jedidiah Perdue, MD. Dr. Perdue has disclosed no relevant financial or other interests in any commercial companies pertaining to this educational activity.

REVIEW OF: Vourc’h M et al, JAMA 2021;325(8):732–741

STUDY TYPE: Randomized clinical trial

It’s known that people who drink unhealthy amounts of alcohol are more likely to get agitated if they’re admitted to the ICU. What to do about it is less well understood. In this study, researchers reasoned that mimicking some of alcohol’s effects with the GABA-B agonist baclofen might decrease agitation in patients on mechanical ventilation. The strategy makes sense pharmacologically, and baclofen even has some evidence for treating alcohol use disorder (see CATR, May/Jun 2020), but the results here were short of a slam dunk.

This double-blind, randomized study involving 314 patients was conducted across 18 medical and surgical ICUs. Eligible patients were those with unhealthy alcohol use (greater than seven weekly standard drinks for women, greater than 14 for men) expected to require 24 hours or more of mechanical ventilation. Patients were randomized to placebo or baclofen, which was dosed based on eGFR and added to a standard anesthetic cocktail to maintain light sedation. The amount of baclofen used was quite high: 50–150 mg daily. For context, the FDA’s maximum recommended dose of baclofen is 80 mg daily. Unfortunately, the investigators did not lay out their rationale for choosing such a high dose.

This study’s primary outcome was one or more agitation-related events, such as self-extubation, pulling out lines, leaving against medical advice, and aggression. Researchers also examined a host of secondary outcomes that included 28-day mortality, oversedation, length of stay, and duration of intubation, among others.

Compared to placebo, patients receiving baclofen were significantly less likely to have an agitation-related event (29.7% vs 19.7%). However, the baclofen group had significantly longer ICU stays (14 vs 11 days), spent more time in deep sedation (7.0 vs 4.6 days), and had fewer vent-free days (14 days vs 19) than placebo. Mortality and other secondary outcomes were similar between the groups.

This study had several notable limitations. First, it lacked a validated method of quantifying alcohol intake other than self-report. We simply don’t know how much alcohol patients drank. Another limitation, probably more significant, was the lack of a delirium assessment. Other GABAergic medications, such as benzodiazepines, are associated with delirium, so baclofen could plausibly have increased rates of delirium in these patients as well—however, we don’t know if that occurred in this study. Alcohol withdrawal delirium (AWD) can be a source of agitation in itself and is treated by GABAergic medications, so it is not clear whether baclofen was treating AWD or agitation-related events stemming from some other etiology.

Carlat Take

Baclofen, at high doses, may modestly reduce agitation among ventilated patients with unhealthy alcohol use but at the cost of longer ICU stays and more time on mechanical ventilation. At this point, we would not recommend using high doses of baclofen prophylactically to prevent agitation in the ICU.

KEYWORDS alcohol use disorder delirium withdrawal
Jedidiah Perdue, MD, MPH

Does CBT Enhance Pharmacotherapy for Addiction?

More from this author
www.thecarlatreport.com
Issue Date: May 1, 2022
SUBSCRIBE NOW
Table Of Contents
Urine Drug Screens: What You Need to Know
Lab Testing for Patients with Substance Use Disorders
Treating Agitation in ICU Patients with AUD?
Opioid Agonist Treatment and Decreased Mortality
Learning Objectives, Laboratory Testing, CATR, May/June 2022
CME Post-Test - Labrotory Testing, CATR, May/June 2022
DOWNLOAD NOW
Featured Book
  • AUDFB1e_CoilBound_Graphic2_transparent_sm.png

    Treating Alcohol Use Disorder: A Fact Book (2023)

    All the tools and information needed to assess and treat your patients who are struggling with...
    READ MORE
Featured Video
  • therapist_canstockphoto9201097.jpg
    General Psychiatry

    Using SAMe In Clinical Practice with Garrett Rossi, MD

    Read More
Featured Podcast
  • canstockphoto4921771.jpg
    General Psychiatry

    Psychopharm Commandment #6: MAOIs

    MAOIs rank high in efficacy and are pretty well tolerated too, as long as you watch for two critical interactions.

    Listen now
Recommended
  • Approaches to Autism Intervention

    January 31, 2022
    canstockphoto2240982_child-bubbles_thumb.jpg
  • Currently Available Cannabis Products

    September 1, 2022
  • Interpreting Assessment Discrepancies from Multiple Sources

    October 17, 2022
    ChildAssessment.png
  • Approaches to Autism Intervention

    January 31, 2022
    canstockphoto2240982_child-bubbles_thumb.jpg
  • Currently Available Cannabis Products

    September 1, 2022
  • Interpreting Assessment Discrepancies from Multiple Sources

    October 17, 2022
    ChildAssessment.png
  • Approaches to Autism Intervention

    January 31, 2022
    canstockphoto2240982_child-bubbles_thumb.jpg
  • Currently Available Cannabis Products

    September 1, 2022
  • Interpreting Assessment Discrepancies from Multiple Sources

    October 17, 2022
    ChildAssessment.png

About

  • About Us
  • CME Center
  • FAQ
  • Contact Us

Shop Online

  • Newsletters
  • Multimedia Subscriptions
  • Books
  • eBooks
  • ABPN Self-Assessment Courses

Newsletters

  • The Carlat Psychiatry Report
  • The Carlat Child Psychiatry Report
  • The Carlat Addiction Treatment Report
  • The Carlat Hospital Psychiatry Report
  • The Carlat Geriatric Psychiatry Report

Contact

info@thecarlatreport.com

866-348-9279

PO Box 626, Newburyport MA 01950

Follow Us

Please see our Terms and Conditions, Privacy Policy, Subscription Agreement, Use of Cookies, and Hardware/Software Requirements to view our website.

© 2023 Carlat Publishing, LLC and Affiliates, All Rights Reserved.