Antidepressants - Articles - Page 3

Research Update

Does Childhood Maltreatment Reduce Response to Antidepressant Treatment?

September 1, 2022

Brian Miller, MD, PhD, MPH. Professor of Psychiatry at the Medical College of Georgia, Augusta, and President of the Georgia Psychiatric Physicians Association.

Dr. Miller, author of this educational activity, receives research support from Augusta University; the National Institute of Mental Health; the Brain and Behavior Research Foundation; and the Stanley Medical Research Institute. Relevant financial relationships listed for the author have been mitigated.

From response rates to adverse effects, this reanalysis of an older trial brings new answers on how a history of abuse and neglect affects antidepressant response.

Rethinking Topiramate

August 1, 2022

Chris Aiken, MD and Kellie Newsome, PMHNP

Topiramate can cause psychosis, or treat psychosis; worsen cognition, or improve it; cause depression or… You get the point. A look at the paradoxical world of psychopharmacology.

What Gets in the Way of Antidepressants?

August 1, 2022

Chris Aiken, MD and Garrett Rossi, MD.

Garrett Rossi, MD.
Inpatient/consult attending psychiatrist, AtlantiCare Regional Medical Center, Pomona, NJ.

Chris Aiken, MD.
Editor-in-Chief, The Carlat Psychiatry Report. Practicing psychiatrist, Winston-Salem, NC.

Dr. Rossi and Dr. Aiken, authors for this educational activity, have no relevant financial relationship(s) with ineligible companies to disclose.

Recent research has added to our understanding of factors that inhibit response to treatment, including major stress, nonadherence, and anxiety.

How Essential Is Antidepressant Continuation?

June 1, 2022

Michael Posternak, MD

Michael Posternak, MD. Dr. Posternak has disclosed no relevant financial or other interests in any commercial companies pertaining to this educational activity.

A landmark study puts a spotlight on whether patients can successfully taper off their antidepressant without relapsing.

Tricyclic Antidepressants: When and How to Use Them

May 1, 2022

Edmund S. Higgins, MD. Clinical associate professor, Psychiatry and Behavioral Sciences, Medical University of South Carolina. Dr. Higgins has disclosed no relevant financial or other interests in any commercial companies pertaining to this educational activity.

Tricyclics have been used in psychiatry since the 1950s, when imipramine was introduced as the first mass-marketed antidepressant. Fluoxetine and the other SSRIs largely supplanted the tricyclics in the 1990s, but these medications still have their uses.

CLINICAL UPDATE

Antidepressants: When Dosage Matters

April 5, 2022

Rehan Aziz, MD.

Rehan Aziz, MD. Associate Professor of Psychiatry and Neurology, Rutgers Robert Wood Johnson Medical School. Dr. Aziz has disclosed no relevant financial or other interests in any commercial companies pertaining to this educational activity.

When it comes to antidepressants, bigger is not better. Here we review the optimal dose ranges for antidepressants, describe how higher doses can worsen symptoms, and show you how to talk to patients about the issue.

Psilocybin vs Escitalopram for Depression

September 10, 2021

Michael Posternak, MD.

Michael Posternak, MD. Dr. Posternak has disclosed no relevant financial or other interests in any commercial companies pertaining to this educational activity.

Psilocybin is inching its way toward FDA approval in depression, but will this trial from the New England Journal of Medicine help it along or set it back?

Comparison of GI Side Effects of Antidepressants

August 3, 2021

Jesus Ligot, MD.

Jesus Ligot, MD. Dr. Ligot has disclosed no relevant financial or other interests in any commercial companies pertaining to this educational activity.

Modern antidepressants are ranked by their risk of GI side effects, with a few surprises baked in.

Antidepressants Harm Some With Bipolar Depression

March 26, 2021

Chris Aiken, MD.

Chris Aiken, MD. Dr. Aiken has disclosed no relevant financial or other interests in any commercial companies pertaining to this educational activity.

This new study is the first placebo-controlled trial to examine the long-term effects of an SSRI in bipolar disorder.

How to Come Off a Psych Med Part 2: Antidepressants, Stimulants, and Benzos

March 11, 2021

Swapnil Gupta, MD

Swapnil Gupta, MD

Associate Professor at Icahn School of Medicine at Mount Sinai. Co-author of Deprescribing in Psychiatry (Oxford, 2019). Dr. Gupta has disclosed that she has no relevant financial or other interests in any commercial companies pertaining to this educational activity.

What do you do when a patient comes to you on a high dose of Adderall and Klonopin without any clear reason to be on them? Swapnil Gupta tackles this in part II of our interview on deprescribing, and describes how to fine-tune and microdose antidepressants and benzodiazepines to manage withdrawal symptoms.