In December 2021, the FDA approved lumateperone (Caplyta) for bipolar I and II depression, and here we report on one of the trials that led to that approval.

With so few pharmacologic options for methamphetamine use disorder, a large trial from The New England Journal of Medicine suggest bupropion and naltrexone are worth exploring.

Gordon Parker takes on the DSM and offers up a practical approach to diagnosing bipolar disorder. Included is a new self-rated scale that Dr. Parker developed to separate normal good moods from hypomania.

The health benefits of light therapy are expanding its use beyond winter depression. Here we explore those promises and pitfalls, including ADHD, PTSD, bipolar depression, binge eating, sleep disorders, dementia, sexual dysfunction, traumatic brain injury, diabetes, and arthritis.

Textbooks tell us that patients with bipolar I disorder need to take mood stabilizers for life. But what are the real risks of stopping these medications? A new meta-analysis provides some clarity.

This new study is the first placebo-controlled trial to examine the long-term effects of an SSRI in bipolar disorder.

Lamotrigine is approved for the prevention of bipolar episodes, but Dr. Aiken explains why it may also treat active bipolar depression. This mood stabilizer is among the most tolerable in its class, and has additional benefits in OCD, borderline personality disorder, and depersonalization disorder.

There are many mood stabilizers to choose from, but which ones are the best tolerated? This meta-analysis looks at how they stack up in terms of weight gain, sedation, and overall discontinuation.

An atypical antipsychotic with a novel mechanism shows promise in bipolar depression.

With Vrylar’s new approval, there are now four atypicals antipsychotics with an indication in bipolar depression. Only two of these, however, are known to work in mania as well as depression. None of the atypicals stands out as the perfect choice for bipolar depression, but there are pros and cons to each that make them fitter better with certain patients.