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Home » research_updates

Articles Tagged with ''research_updates''

High-Dose Citalopram and Escitalopram: Undeserved Bad Rap?

April 1, 2017
Colleen Ryan, MD
From The Carlat Psychiatry Report
Issue Links: Learning Objectives | Editorial Information | PDF of Issue
Colleen Ryan, MD Dr. Ryan has disclosed that she has no relevant financial or other interests in any commercial companies pertaining to this educational activity.
Selective serotonin reuptake inhibitors (SSRIs) are considered the first-line treatment for depression; however, our confidence in their safety took a hit when the FDA issued a warning in 2011 about doses of citalopram above 40 mg causing QTc prolongation.
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Statins and SSRIs Together Lead to Better Outcomes in Depression

November 30, 2016
From The Carlat Psychiatry Report
Issue Links: Learning Objectives | Editorial Information | PDF of Issue
Is depression a disorder of inflammation? This intriguing hypothesis has been floating around in the literature over the past few years. Thus far, the findings are suggestive but not definitive. For instance, one marker of inflammation, C-reactive protein, was found to be higher in people with psychological distress and depression.
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Large Study Finds Antipsychotic Use During First Trimester Does Not Increase Risk of Malformations

November 30, 2016
From The Carlat Psychiatry Report
Issue Links: Learning Objectives | Editorial Information | PDF of Issue
The use of antipsychotics during pregnancy has doubled over the past decade, and there have been ongoing concerns about the risk of congenital malformations. In the May issue of TCPR, we reviewed a pregnancy registry study showing no significant association between atypical antipsychotic use and major malformation.
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SSRIs May Work More Quickly in Pediatric OCD Than You Realize

November 1, 2016
From The Carlat Child Psychiatry Report
Issue Links: Learning Objectives | Editorial Information | PDF of Issue
Bret A. Moore, PsyD, ABPP
The pharmacological treatment of obsessive-compulsive disorder (OCD) for adults is pretty well worked out. Selective serotonin reuptake inhibitors (SSRIs) are the gold-standard treatment. We have multiple randomized, placebo-controlled trials to back this up. However, we know less about medication treatment of OCD for children.
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Metformin Use in Autistic Children Taking Atypical Antipsychotics

November 1, 2016
From The Carlat Child Psychiatry Report
Issue Links: Learning Objectives | Editorial Information | PDF of Issue
Bret A. Moore, PsyD, ABPP
Atypical antipsychotics are commonly used to reduce irritability and agitation in children with autism spectrum disorder (ASD). Although effective, these medications lead to weight gain and other metabolic problems. Strategies like tailored diet plans and exercise can help, but they are often not enough. If not interrupted early, for many, continued weight gain will lead to diabetes, hypertension, and heart disease later in life.
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Whole-Body Hyperthermia for Depression: Effective or Too Early to Tell?

October 17, 2016
Bret A. Moore, PsyD, ABPP
...
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Efficacy of Quetiapine in PTSD

October 17, 2016
Bret A. Moore, PsyD, ABPP
...
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Treating Complicated Grief: Grief-Focused Psychotherapy Is More Effective Than Citalopram

September 28, 2016
Bret A. Moore, PsyD, ABPP
...
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Vilazodone Not Effective for Cannabis Dependence

September 1, 2016
From The Carlat Addiction Treatment Report
Issue Links: Learning Objectives | Editorial Information
Bret A. Moore, PsyD, ABPP
Effective pharmacological treatments for cannabis dependence have eluded the field of addiction psychiatry. It’s not, however, due to a lack of trying. Theoretical connections between cannabinoids and the serotonin system have spurred a number of studies looking at the usefulness of SSRIs and buspirone.
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Combining Alcohol With Caffeinated Energy Drinks Leads to Increased Alcohol Consumption

September 1, 2016
From The Carlat Addiction Treatment Report
Issue Links: Learning Objectives | Editorial Information
Bret A. Moore, PsyD, ABPP
Combining caffeine-based energy drinks and alcohol has become a popular practice among social drinkers over the past decade. Users say that the caffeine enhances their buzz and allows them to drink for longer periods of time.
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