Optimal Antidepressant Doses in Major Depression
The Carlat Psychiatry Report, Volume 18, Number 3, March 2020
Topics: Antidepressants | Bupropion | Citalopram | Depression | Depressive Disorder | Escitalopram | Fluoxetine | Mirtazapine | Paroxetine | Pharmacology | Pharmacology Tips | Research | Research Update | Sertraline | SSRIs | Venlafaxine | Wellbutrin
Kristen Gardner, PharmD.
Dr. Gardner has disclosed that she has no relevant financial or other interests in any commercial companies pertaining to this educational activity.
More is not necessarily better in psychopharmacology. Some medications have plateau effect, while others follow a “U-shaped curve,” causing more problems as the dose goes too high. This metaanalysis looked at 77 dose-response trials with antidepressants to quantify their optimal therapeutic window.